ArticleNature2020
Ageing hallmarks exhibit organ-specific temporal signatures.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 445 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
445citing papers in PubMed, 2 pooled it
29.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
445 citing papers in PubMed, 2 syntheses or guidelines pooled it, 664 citations in OpenAlex.
- Shared and niche-specific transcriptional signatures of macrophage aging revealed by a cross-tissue meta-analysis.BMC biology · 2026Pooled it
- [Recent Advances in the Interorgan Regulatory Roles of Adipose Tissue].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Pooled it
- Modeling human neurodegeneration with iPSCs: opportunities, limitations, and the challenge of aging.The Journal of clinical investigation · 2026Review
- Predicting and finding geroprotective compounds through modulating conserved longevity-associated aging modules.Science advances · 2026Article
- Asprosin-driven metabolic-epigenetic rewiring attenuates mesenchymal stem cell senescence with therapeutic benefits for infarcted hearts.Journal of advanced research · 2026Article
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- Pulsed electromagnetic fields activate a peripheral interoceptive pathway to suppress sympathetic Npy for osteogenesis.Nature communications · 2026Article
- Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Lactate Receptor Activation Alleviates Senescence and Preserves Homeostasis of Aged Arteries.bioRxiv : the preprint server for biology · 2026Article
- MA-5 attenuates disease-associated transcriptomic aging and pathological microglial states in Gaucher disease.Research square · 2026Article
- Natural Killer Cell Dysfunction Is Emerging During Midlife Obesity.Aging cell · 2026Article
- Mapping structural aging across human tissues reveals tissue-specific trajectories and coordinated deterioration.Nature aging · 2026Article
- Article
- Hippocampal snRNA-seq in Collaborative Cross reveals molecular signatures of cognitive resilience independent of chronological aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Treating age-related loss of muscle mass and function: Where should we be focusing?The Journal of physiology · 2026Review
- Sex-specific trajectories of nonlinear immune aging at single-cell level.Nature communications · 2026Article
- Mitochondrial stress activates ELT-2-dependent lysosomal proteostasis to extend lifespan inScience advances · 2026Article
- AAV-mediated FGF21 gene therapy promotes health span extension by whole-body tissue-specific adaptations.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Embracing non-linearity in human ageing.Nature reviews. Genetics · 2026Review
- Dilating the aging clock with light.Innovation (Cambridge (Mass.)) · 2026Review
385 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 15 institutions in 5 countries.
Nicholas Schaum *Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Benoit Lehallier *Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-7452-3785
Oliver Hahn *Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Róbert PálovicsDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Shayan HosseinzadehChan Zuckerberg Biohub, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8270-0582
Song E LeeDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Rene SitChan Zuckerberg Biohub, San Francisco, CA, USA.
Davis P LeeDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Patricia Morán LosadaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Macy E ZardenetaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Tobias FehlmannChair for Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.
James T WebberChan Zuckerberg Biohub, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8594-9888
Aaron McGeeverChan Zuckerberg Biohub, San Francisco, CA, USA.
Kruti CalcuttawalaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Hui ZhangDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6787-7403
Daniela BerdnikDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Vidhu MathurDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Weilun TanChan Zuckerberg Biohub, San Francisco, CA, USA.
Alexander ZeeChan Zuckerberg Biohub, San Francisco, CA, USA.
Michelle TanChan Zuckerberg Biohub, San Francisco, CA, USA.
Tabula Muris Consortium
Angela Oliveira PiscoChan Zuckerberg Biohub, San Francisco, CA, USA.
Jim KarkaniasChan Zuckerberg Biohub, San Francisco, CA, USA.
Norma F NeffChan Zuckerberg Biohub, San Francisco, CA, USA.
Andreas KellerDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-5361-0895
Spyros DarmanisChan Zuckerberg Biohub, San Francisco, CA, USA.
Stephen R QuakeChan Zuckerberg Biohub, San Francisco, CA, USA. steve@quake-lab.org.ORCID http://orcid.org/0000-0002-1613-0809
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA. twc@stanford.edu.ORCID http://orcid.org/0000-0001-5893-0831
Stanford University · USChan Zuckerberg Initiative (United States) · USUniversity of California, San Francisco · USHoward Hughes Medical Institute · USSaarland University · DEVA Palo Alto Health Care System · USNeurosciences Institute · USCanadian Institute for Advanced Research · CACardiovascular Institute of the South · USHarvard University · USJagiellonian University · PLPalo Alto University · USPrincess Máxima Center · NLStanford Medicine · USUniversity of Pittsburgh · US
Funding
UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Y. Chen · 1986 to 2026
$30.7MStanford Training Program in Aging ResearchT32AG047126 · NIA · STANFORD UNIVERSITY · PI VYJEYANTHI S PERIYAKOIL, TONY WYSS-CORAY · 2014 to 2026
$4.3MEnabling Technologies for Human-Machine Hybrid TissuesDP1LM012179 · NLM · STANFORD UNIVERSITY · PI WU, SEAN M · 2014 to 2018
$3.8MA Bioorthogonal Approach to Study Mammalian AgingDP1AG053015 · NIA · STANFORD UNIVERSITY · PI WYSS-CORAY, TONY · 2015 to 2019
$3.7MCirculatory Rejuvenating Factors for the BrainR01AG045034 · NIA · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI WYSS-CORAY, TONY · 2013 to 2017
$1.4MReverse Engineering the Alveolus: From cellular to microenvironment specification during developmentR00HL127267 · NHLBI · MAYO CLINIC ROCHESTER · PI BROWNFIELD, DOUGLAS GLENN · 2019 to 2021
$747kMesenchymal Stem Cells as Determinants of Tissue AgingK99AG053438 · NIA · STANFORD UNIVERSITY · PI WOSCZYNA, MICHAEL · 2016 to 2017
$202kBLR&D Research Career Scientist Award ApplicationIK6BX004599 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI WYSS-CORAY, TONY · 2019 to 2020
–Microglial dysfunction in brain aging and Alzheimer's diseaseI01BX004544 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI WYSS-CORAY, TONY · 2019 to 2020
–BLRD VA I01 BX004544BLRD VA IK6 BX004599NHLBI NIH HHS R00 HL127267NIA NIH HHS DP1 AG053015NIA NIH HHS DP1-AG053015NIA NIH HHS K99 AG053438NIA NIH HHS R01 AG045034NIA NIH HHS T32 AG047126NIDDK NIH HHS P30 DK026743NLM NIH HHS DP1 LM012179
Abstract
Ageing is the single greatest cause of disease and death worldwide, and understanding the associated processes could vastly improve quality of life. Although major categories of ageing damage have been identified-such as altered intercellular communication, loss of proteostasis and eroded mitochondrial function
Indexed as
Gene Expression RegulationAgingAnimalsBlood ProteinsFemaleImmunoglobulin J-ChainsMaleMiceOrgan SpecificityPlasma CellsRNA, MessengerRNA-SeqSingle-Cell AnalysisTime FactorsT-LymphocytesTranscriptomeBlood ProteinsImmunoglobulin J-ChainsRNA, Messenger
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.