ArticleNature2020
A universal trade-off between growth and lag in fluctuating environments.
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In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers.
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142citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
142 citing papers in PubMed.
- Trade-off between flux efficiency and metabolic control shapes enzyme allocation.Molecular systems biology · 2026Article
- Coarse-grained resource allocation modeling for decoding and rewiring microbial metabolism.Trends in microbiology · 2026Review
- Synergistic degradation of fucoidans in the ocean.Nature · 2026Article
- Twenty-Five Years of the Environmental Stress Response and the Enduring Power of Yeast in Stress Biology.Yeast (Chichester, England) · 2026Review
- Increased nutrient diversity can induce loss of microbial diversity through enhanced resource uptake.Nature ecology & evolution · 2026Article
- Article
- Seasonal thawing of high Arctic soils triggers selective microbial growth and predation.mSystems · 2026Article
- On the conditions for shifts in metabolic strategies.PLoS computational biology · 2026Review
- Fitness advantage of sequential metabolic strategies emerges from community interactions in strongly fluctuating environments.PLoS computational biology · 2026Article
- Machine Learning Reveals Quantitative Amino Acid Preferences in Bifidobacterium longum Growth.Microbial biotechnology · 2026Article
- Physiological architecture and evolutionary origins of cellular adaptability.bioRxiv : the preprint server for biology · 2026Article
- Mechanistic insights into E. coli recovery from growth arrest.Nature communications · 2026Article
- The importance of regulated resource reallocation during dynamic environmental shifts in yeast.The EMBO journal · 2026Article
- A proteome optimal allocation model for elucidating effects of temperature on bacterial growth.NPJ systems biology and applications · 2026Article
- Growth dynamics of 3,909 Escherichia coli single-gene knockouts in rich and minimal media.Scientific data · 2026Article
- Rapid Adaptation to Road Salts in a Freshwater Microbial Eukaryote.Ecology and evolution · 2026Article
- Mechanistic two-pathway modeling of substrate inhibition in lactic acid bacteria for enhanced fermentation control.Quantitative biology (Beijing, China) · 2026Article
- Large-scale testing of antimicrobial lethality at single-cell resolution predicts mycobacterial infection outcomes.Nature microbiology · 2026Article
- Dipiperazine-Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram-Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Keystone bacterial taxa drive denitrification and NEnvironmental microbiome · 2026Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors.
Markus Basan *Department of Systems Biology, Harvard Medical School, Boston, MA, USA. markus@hms.harvard.edu.ORCID http://orcid.org/0000-0002-9396-521X
Tomoya Honda *Section of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-2391-4799
Dimitris ChristodoulouInstitute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-0646-6181
Manuel HörlInstitute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.
Yu-Fang ChangDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.
Emanuele LeonciniDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5387-118X
Avik MukherjeeDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6190-5223
Hiroyuki OkanoDepartment of Physics, University of California at San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-8198-1354
Brian R TaylorDepartment of Physics, University of California at San Diego, La Jolla, CA, USA.
Josh M SilvermanDepartment of Integrative Structural and Computational Biology, and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.
Carlos SanchezDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0909-0909
James R WilliamsonDepartment of Integrative Structural and Computational Biology, and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-8772-468X
Johan PaulssonDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8671-4914
Terence HwaSection of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA, USA. thwa@ucsd.edu.ORCID http://orcid.org/0000-0003-1837-6842
Uwe SauerInstitute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland. sauer@imsb.biol.ethz.ch.ORCID http://orcid.org/0000-0002-5923-0770
Funding
Dynamics of the Bacterial Ribosome and Proteome (Equipment Supplement)R35GM136412 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI James R Williamson · 2020 to 2026
$4.9MQuantitative Studies of Bacterial Growth PhysiologyR01GM095903 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HWA, TERENCE · 2011 to 2023
$3.8MQuantitative Studies of Metabolic Switches in enteric bacteriaR01GM109069 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HWA, TERENCE · 2014 to 2022
$3.0MDynamics of the Bacterial ProteomeR01GM118850 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI WILLIAMSON, JAMES R · 2016 to 2019
$1.6MNIGMS NIH HHS R01 GM095903NIGMS NIH HHS R01 GM109069NIGMS NIH HHS R01 GM118850NIGMS NIH HHS R35 GM136412
Abstract
The rate of cell growth is crucial for bacterial fitness and drives the allocation of bacterial resources, affecting, for example, the expression levels of proteins dedicated to metabolism and biosynthesis
Indexed as
Adaptation, PhysiologicalEnvironmentAcetatesBacillus subtilisCell DivisionEscherichia coliFermentationGluconeogenesisGlucoseGlycolysisMetabolomicsModels, BiologicalMutationSaccharomyces cerevisiaeAcetatesGlucose
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.