ArticleNature2020
Fasting-mimicking diet and hormone therapy induce breast cancer regression.
Erratum issued 2 registry-linked trialsOpen access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 194 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
194citing papers in PubMed, 3 pooled it
26.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Targeting Triple Negative BREAst Cancer Metabolism With a Combination of Chemoimmunotherapy and a FASTing-like Approach in the Preoperative Setting: the BREAKFAST 2 Trial
Use of a Fasting Mimicking Diet in Patients Undergoing Chemotherapy for Gynecologic Malignancies
Who cites it
194 citing papers in PubMed, 3 syntheses or guidelines pooled it, 340 citations in OpenAlex.
- Fasting-mimicking diets as a strategy to reprogram tumor metabolism: a systematic review.European journal of nutrition · 2026Pooled it
- Pooled it
- The effects of time-restricted eating for patients with nonalcoholic fatty liver disease: a systematic review.Frontiers in nutrition · 2023Pooled it
- Effect of fasting-mimicking diet on markers of autophagy and metabolic health in human subjects.GeroScience · 2026Trial
- A Pilot Randomized Control Trial to Assess the Adjunctive Effect of Diet on Response to Advanced Therapies in Patients With Ulcerative Colitis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025Trial
- The Effect of Diet on Breast Cancer Recurrence: The DIANA-5 Randomized Trial.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Trial
- Fasting-Mimicking-Diet does not reduce skeletal muscle function in healthy young adults: a randomized control trial.European journal of applied physiology · 2022Trial
- Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer.Cancer discovery · 2022Trial
- Trial
- A fasting-mimicking environment enhances procaspase-activating compound 1 in 2D and 3D glioma cell models.Cell cycle (Georgetown, Tex.) · 2026Article
- Intermittent Fasting Reduces Taurine Availability and Promotes Antitumor Immunity Through PERK Attenuation-Associated Paraptosis-Like Cell Death in Colorectal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Senescent obesity signature in breast cancer: a paradigm of reverse cardio-oncology.European heart journal · 2026Review
- Autophagy modulation in cancer.Nature reviews. Drug discovery · 2026Review
- Ketogenic Diet as an Adjuvant in Epithelial Cancers: Mechanisms, Model Systems, and Translational Opportunities.Cancers · 2026Review
- RagC senses β-hydroxybutyrate abundancy to suppress mTORC1.Protein & cell · 2026Article
- The lethal symbiont: exploring the pathophysiology of cancer.Physiological reviews · 2026Review
- The CHRONO trial: Protocol for a randomized controlled trial of early time-restricted eating in patients with breast or rectal cancer.Nutrition research (New York, N.Y.) · 2026Article
- Fasting-mimicking diet counteracts gut microbial dysbiosis in experimental lynch syndrome.Cancer & metabolism · 2026Article
- Effects of Intermittent Fasting-Mimicking Diet on Pancreatic Islet Plasticity: Immunohistochemical, Ultrastructural, and Metabolic Profiles.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Leveraging Dietary Interventions to Benefit Patients with Hematologic Malignancies and Clonal Hematopoiesis.Nutrients · 2026Review
134 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
34 authors at 7 institutions in 3 countries.
Irene Caffa *IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Vanessa Spagnolo *Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Claudio VernieriIFOM, FIRC Institute of Molecular Oncology, Milan, Italy.
Francesca ValdemarinIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Pamela BecheriniIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Min WeiLongevity Institute, Leonard Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Sebastian BrandhorstLongevity Institute, Leonard Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Chiara ZucalDepartment of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, Trento, Italy.
Else DriehuisOncode Institute and Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Utrecht, The Netherlands.
Lorenzo FerrandoDepartment of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy.ORCID http://orcid.org/0000-0002-4025-7930
Francesco PiacenteIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Alberto TagliaficoDepartment of Health Sciences, University of Genoa, Genoa, Italy.
Michele CilliIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Luca MastracciIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Valerio G VelloneIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Silvano PiazzaDepartment of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, Trento, Italy.ORCID http://orcid.org/0000-0002-7156-5434
Anna Laura CremoniniIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Raffaella GradaschiIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Carolina ManteroIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Mario PassalacquaDepartment of Experimental Medicine, University of Genoa, Genoa, Italy.ORCID http://orcid.org/0000-0003-2779-6259
Alberto BallestreroIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Gabriele ZoppoliIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Michele CeaIRCCS Ospedale Policlinico San Martino, Genoa, Italy.ORCID http://orcid.org/0000-0003-3345-0799
Annalisa ArrighiDepartment of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy.
Patrizio OdettiIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Fiammetta MonacelliIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Giulia SalvadoriDepartment of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0001-5175-2868
Salvatore CortellinoIFOM, FIRC Institute of Molecular Oncology, Milan, Italy.
Hans CleversOncode Institute and Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-3077-5582
Filippo De BraudDepartment of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Samir G SukkarIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Alessandro ProvenzaniDepartment of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, Trento, Italy.
Valter D Longo *IFOM, FIRC Institute of Molecular Oncology, Milan, Italy. vlongo@usc.edu.ORCID http://orcid.org/0000-0002-0946-7534
Alessio Nencioni *IRCCS Ospedale Policlinico San Martino, Genoa, Italy. alessio.nencioni@unige.it.ORCID http://orcid.org/0000-0001-5068-8884
Ospedale Policlinico San Martino · ITUniversity of Genoa · ITUniversity of Milan · ITUniversity of Southern California · USUniversity of Trento · ITIFOM · ITRoyal Netherlands Academy of Arts and Sciences · NL
Funding
Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3MThe Role of the Glucose-regulated Protein GRP78/BiP in Stress Resistance and AginP01AG034906 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LONGO, VALTER D. · 2011 to 2016
$9.3MRole of Longevity Regulatory Pathways in Age-dependent Macro-molecular Damage inR01AG020642 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LONGO, VALTER D. · 2003 to 2017
$4.8MNCATS NIH HHS UL1 TR001855NIA NIH HHS AG034906NIA NIH HHS AG20642NIA NIH HHS P01 AG034906NIA NIH HHS R01 AG020642
Abstract
Approximately 75% of all breast cancers express the oestrogen and/or progesterone receptors. Endocrine therapy is usually effective in these hormone-receptor-positive tumours, but primary and acquired resistance limits its long-term benefit
Indexed as
AnimalsBiological FactorsBreast NeoplasmsDiet, HealthyDiet TherapyDisease Models, AnimalDisease ProgressionDrug Resistance, NeoplasmEarly Growth Response Protein 1FastingFemaleFulvestrantHumansInsulinInsulin-Like Growth Factor ILeptinBiological FactorsEarly Growth Response Protein 1Egr1 protein, mouseFulvestrantInsulininsulin-like growth factor-1, mouseInsulin-Like Growth Factor ILeptinpalbociclibPiperazinesPTEN PhosphohydrolasePten protein, mousePyridinesReceptors, EstrogenReceptors, ProgesteroneTamoxifen
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
NCT05763992ClinicalTrials.gov
NCT06376604ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.