ArticleNature2020
Nucleolar RNA polymerase II drives ribosome biogenesis.
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Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.
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132citing papers in PubMed
11.3field-weighted citation impact, top 1% of its field
What it found
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Who cites it
132 citing papers in PubMed, 211 citations in OpenAlex.
- Novel RNA polymerase I and cyclin-dependent kinase combination therapy for the treatment of aggressive acute myeloid leukemia.Leukemia · 2026Article
- RAD54L coordinates the nucleolar DNA damage response to maintain rDNA stability.The EMBO journal · 2026Article
- Elucidating structure-function relationships in the mammalian nucleolus.Nature reviews. Molecular cell biology · 2026Review
- The Nucleolus in Human Disease: Ribosome Biogenesis, Nucleolar Surveillance, and Therapeutic Opportunities.Biomolecules · 2026Review
- Ribosome biogenesis in osteoarthritis: mechanisms and therapeutic potential.Journal of translational medicine · 2026Review
- Embryo-scale Visual Cell Sorting reveals a conserved transcriptomic signature of nucleolar size linked to proteostasis.bioRxiv : the preprint server for biology · 2026Article
- The interaction between virus-bound KLF4 and host-bound PARP1 directs the localization of wild-type adeno-associated virus type 2 (wtAAV2) to cellular sites of DNA damage.Journal of virology · 2026Article
- Mathematical modeling of ribosome competition informs testable treatment strategies for drug-tolerant cancer persister cells.iScience · 2026Article
- Chromatin association promotes UBR5-mediated degradation of Rb.bioRxiv : the preprint server for biology · 2026Article
- When R-Loops Go Awry: Genome Instability and Neurological Diseases.The European journal of neuroscience · 2026Review
- Regulation of Chemical Transformation in Designer Peptide Biomolecular Condensates.ACS applied materials & interfaces · 2026Article
- Article
- In silico mapping of non-canonical DNA structures across the human ribosomal DNA locus.G3 (Bethesda, Md.) · 2026Article
- Review
- Labeling of nascent RNA in the C. elegans intestine.PloS one · 2026Article
- Nucleolar expansion: A biomolecular condensate mortality timer.Geromedicine · 2026Article
- Amyloid-bodies in the evolution of malignancies.PloS one · 2026Article
- The cancer-testis lncRNA LINC01940 promotes gastric cancer malignant progression and chemoresistance by enhancing ribosome biogenesis via TAF15-mediated NOL11 SUMOylation.Cellular & molecular biology letters · 2025Article
- RNA Pol-II transcripts in nucleolar associated domains of cancer cell nucleoli.Nucleus (Austin, Tex.) · 2025Article
- CDK9 is a dependency in GATA-3 driven and MCL-1 independent T-cell Lymphomas.Blood cancer journal · 2025Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 5 institutions in 2 countries.
Karan J Abraham *Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-6221-4915
Negin Khosraviani *Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-0588-3618
Janet N Y ChanDepartment of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Aparna GorthiGreehey Children's Cancer Research Institute, Department of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, TX, USA.
Anas SammanDepartment of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-3772-4152
Dorothy Y ZhaoDepartment of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Miling WangSylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Michael BokrosSylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Elva VidyaDepartment of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Lauren A OstrowskiDepartment of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-6922-6196
Roxanne OshidariDepartment of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-4330-1570
Violena PietrobonDepartment of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Parasvi S PatelPrincess Margaret Cancer Research Centre, University Health Network, and Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Arash AlgounehDepartment of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Rajat SinghaniaPrincess Margaret Cancer Research Centre, University Health Network, and Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Yupeng LiuDepartment of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-9871-1905
V Talya YerliciDepartment of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Daniel D De CarvalhoPrincess Margaret Cancer Research Centre, University Health Network, and Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Michael OhhDepartment of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-7600-4751
Brendan C DicksonDepartment of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-2269-6216
Razq HakemPrincess Margaret Cancer Research Centre, University Health Network, and Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Jack F GreenblattDepartment of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Stephen LeeSylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Alexander J R BishopGreehey Children's Cancer Research Institute, Department of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-5742-4387
Karim MekhailDepartment of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. karim.mekhail@utoronto.ca.ORCID http://orcid.org/0000-0002-6084-020X
University of Toronto · CAUniversity Health Network · CAUniversity of Miami · USThe University of Texas Health Science Center at San Antonio · USMount Sinai Hospital · CA
Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1MCancer Biology Training ProgramT32CA148724 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Pei Wang, Feng-Chun Yang · 2011 to 2026
$3.3MThe Nucleolar Detention Center: a Hub of Long Noncoding RNAs that Imprison Proteins During StressR01GM115342 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LEE, STEPHEN · 2015 to 2022
$2.6MDysregulated transcription processes in Ewing sarcoma:R01CA241554 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BISHOP, ALEXANDER JAMES · 2020 to 2025
$2.3MNRSA Training Core (TL1)TL1TR002647 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CHUN, YONG-HEE PATRICIA, FREI, CHRISTOPHER R. · 2018 to 2022
$1.8MInduction of Tumor Cell Dormancy by Ribosomal Intergenic Spacer Noncoding RNAR01CA200676 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LEE, STEPHEN · 2016 to 2020
$1.7MImproving etoposide treatment of Ewing's sarcomaR01CA152063 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BISHOP, ALEXANDER JAMES · 2011 to 2015
$1.5MCancer Epigenetics Training ProgramT32CA217835 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI FIGUEROA, MARIA EUGENIA, MOREY, LLUIS · 2018 to 2022
$1.3MA screen for damage response genes using recombinationK22ES012264 · NIEHS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BISHOP, ALEXANDER JAMES · 2004 to 2006
$321kNCATS NIH HHS TL1 TR002647NCI NIH HHS P30 CA054174NCI NIH HHS R01 CA152063NCI NIH HHS R01 CA200676NCI NIH HHS R01 CA241554NCI NIH HHS T32 CA148724NCI NIH HHS T32 CA217835NIEHS NIH HHS K22 ES012264NIGMS NIH HHS R01 GM115342
Abstract
Proteins are manufactured by ribosomes-macromolecular complexes of protein and RNA molecules that are assembled within major nuclear compartments called nucleoli
Indexed as
Cell Line, TumorCell NucleolusCRISPR-Associated Protein 9DNA HelicasesDNA, IntergenicDNA, RibosomalHumansMultifunctional EnzymesProtein BiosynthesisRibonuclease HRibosomesR-Loop StructuresRNA HelicasesRNA Polymerase IRNA Polymerase IIRNA, UntranslatedCRISPR-Associated Protein 9DNA HelicasesDNA, IntergenicDNA, RibosomalMultifunctional EnzymesRibonuclease Hribonuclease HIRNA HelicasesRNA Polymerase IRNA Polymerase IIRNA, UntranslatedSETX protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.