ArticleScientific reports2020
Postoperative statin treatment may be associated with improved mortality in patients with myocardial injury after noncardiac surgery.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Long-term major adverse cardiovascular events following myocardial injury after non-cardiac surgery: meta-analysis.BJS open · 2023Pooled it
- Myocardial injury in noncardiac surgery.Korean journal of anesthesiology · 2022Trial
- Myocardial Injury After Lung Cancer Surgery: Incidence, Characteristics, Risk Factors, and Prognosis: A Retrospective Cohort Study.Annals of surgical oncology · 2026Article
- ASO Author Reflections: Unmasking the Silent Threat: Myocardial Injury After Lung Cancer Surgery and Its Link to Major Adverse Cardiovascular Events.Annals of surgical oncology · 2026Article
- Advances in biomarkers for myocardial injury after non-cardiac surgery.Journal of anesthesia and translational medicine · 2026Review
- Cardiac risk assessment after noncardiac surgery: a historical cohort study on guideline adherence at a Canadian quaternary care centre.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Article
- Cardiac Troponin as a Prognostic Indicator for Major Adverse Cardiac Events in Non-Cardiac Surgery: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Comprehensive review of myocardial injury after noncardiac surgery: prevention, intervention, and long-term management strategies.Journal of cardiothoracic surgery · 2025Review
- Management of Patients with Myocardial Injury After Noncardiac Surgery: A Retrospective Chart Review.CJC open · 2025Article
- Association and Comparison of Systemic Inflammation Indicators and Myocardial Injury After Noncardiac Surgery in Older Patients.Journal of inflammation research · 2025Article
- An anesthesiology-led perioperative outreach service: experience from a Canadian centre and a focused narrative literature review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Review
- Perioperative myocardial injury and infarction after noncardiac surgery: a review of pathophysiology, diagnosis, and management.Frontiers in cardiovascular medicine · 2024Review
- Perioperative Myocardial Injury/Infarction After Non-cardiac Surgery in Elderly Patients.Frontiers in cardiovascular medicine · 2022Review
- Management of Postoperative Myocardial Injury After Non-cardiac Surgery in Patients Aged ≥ 80 Years: Our 10 Years' Experience.Frontiers in cardiovascular medicine · 2022Article
- Predictability of Mortality in Patients With Myocardial Injury After Noncardiac Surgery Based on Perioperative Factors via Machine Learning: Retrospective Study.JMIR medical informatics · 2021Article
- Observational
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myocardial injury after noncardiac surgery (MINS) is recently accepted as a strong predictor of mortality, regardless of symptoms. However, anticoagulation is the only established treatment. This study aimed to evaluate the association between statin treatment and mortality after MINS. From January 2010 to June 2019, a total of 5,267 adult patients who were discharged after the occurrence of MINS were enrolled. The patients were divided into two groups according to statin prescription at discharge. The outcomes were 1-year and overall mortalities. Of the total 5,109 patients, 1,331 (26.1%) patients were in the statin group and 3,778 (73.9%) patients were in the no statin group. The 1-year and overall mortalities were significantly lower in the statin group compared with the no statin group (6.1% vs. 13.3%; hazard ratio [HR], 0.55; 95% confidence interval [CI], 0.41-0.74; p < 0.001 for 1-year mortality and 15.0% vs. 25.0%; HR, 0.62; 95% CI, 0.51-0.76; p < 0.001 for overall mortality). Analyses after inverse probability treatment weighting showed similar results (HR, 0.61; 95% CI, 0.50-0.74; p < 0.001 for 1-year mortality and HR, 0.70; 95% CI, 0.54-0.90; p = 0.006 for overall mortality), and the mortalities did not differ according to the dose of statin. Our results suggest that statin treatment may be associated with improved survival after MINS. A trial is needed to confirm this finding and establish causality.
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