ArticleCommunications biology2020
Multiple signals evoked by unisensory stimulation converge onto cerebellar granule and Purkinje cells in mice.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Polarity-dependent modulation of sensory circuits by cerebellar tDCS: local and distant effects.Scientific reports · 2026Article
- Cerebellar motor and non-motor contributions to dystonia pathophysiology and treatment.Dystonia (Lausanne, Switzerland) · 2026Article
- Polarity-dependent modulation of sensory circuits by cerebellar tDCS: local and distant effects.bioRxiv : the preprint server for biology · 2025Article
- Cerebellar contribution to multisensory integration: A computational modeling exploration.APL bioengineering · 2025Article
- Article
- Heterogeneity in Slow Synaptic Transmission Diversifies Purkinje Cell Timing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cerebellar Functions Beyond Movement and Learning.Annual review of neuroscience · 2024Review
- A Novel Paired Somatosensory-Cerebellar Stimulation Induces Plasticity on Cerebellar-Brain Connectivity.Cerebellum (London, England) · 2024Article
- Head Orientation Modulates Vestibular Cerebellar Evoked Potentials (VsCEPs) and Reflexes Produced by Impulsive Mastoid and Midline Skull Stimulation.Cerebellum (London, England) · 2024Article
- Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum.Nature communications · 2024Article
- The indirect corticopontine pathway relays perioral sensory signals to the cerebellum via the mesodiencephalic junction.iScience · 2023Article
- Excitation and Inhibition Delays within a Feedforward Inhibitory Pathway Modulate Cerebellar Purkinje Cell Output in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neuronal activity patterns in microcircuits of the cerebellar cortical C3 zone during reaching.The Journal of physiology · 2022Article
- Input and output organization of the mesodiencephalic junction for cerebro-cerebellar communication.Journal of neuroscience research · 2022Article
- Cerebro-Cerebellar Networks in Migraine Symptoms and Headache.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
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- Editorial: Information Processing in the Cerebellum.Frontiers in systems neuroscience · 2021Article
- Article
- Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cerebellum receives signals directly from peripheral sensory systems and indirectly from the neocortex. Even a single tactile stimulus can activate both of these pathways. Here we report how these different types of signals are integrated in the cerebellar cortex. We used in vivo whole-cell recordings from granule cells and unit recordings from Purkinje cells in mice in which primary somatosensory cortex (S1) could be optogenetically inhibited. Tactile stimulation of the upper lip produced two-phase granule cell responses (with latencies of ~8 ms and 29 ms), for which only the late phase was S1 dependent. In Purkinje cells, complex spikes and the late phase of simple spikes were S1 dependent. These results indicate that individual granule cells combine convergent inputs from the periphery and neocortex and send their outputs to Purkinje cells, which then integrate those signals with climbing fiber signals from the neocortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.