ArticleScience translational medicine2020
High-loading Gα
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Metrnl Reduces Thrombosis and Acute Myocardial Injury Through Inhibition of Platelet Activation via CD36 Receptor Degradation.Circulation · 2026Article
- Application of nanotherapy in cardiovascular diseases featuring novel pharmacological mechanisms and drug delivery strategies.Discover nano · 2026Review
- Targeting a specific subset of neutrophils to mitigate cardiac reperfusion injury.Research square · 2025Article
- Direct Binding of Lyn to GPIbβ Transmits 2-Way GPIb-IX Signaling to Stimulate Platelet Activation and VWF Binding.Circulation research · 2025Article
- PD-L1-Targeting Biomimetic Photoresponsive Thermosensitive Liposomes for Triple-Negative Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The gut microbiota-bile acid-TGR5 axis orchestrates platelet activation and atherothrombosis.Nature cardiovascular research · 2025Article
- Tapping Into the Natural PZ-Independent Anticoagulant Function of ZPI to Inhibit Thrombosis With Minimal Effect on Hemostasis.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Advances in the treatment of atherosclerosis with ligand-modified nanocarriers.Exploration (Beijing, China) · 2024Review
- Thromboinflammation and the Role of Platelets.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Roles of Integrin in Cardiovascular Diseases: From Basic Research to Clinical Implications.International journal of molecular sciences · 2024Review
- Integrin βNature communications · 2023Article
- Article
- Novel Antithrombotic Agents in Ischemic Cardiovascular Disease: Progress in the Search for the Optimal Treatment.Journal of cardiovascular development and disease · 2022Review
- Galectin 3 enhances platelet aggregation and thrombosis via Dectin-1 activation: a translational study.European heart journal · 2022Article
- Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising Hemostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- GαFrontiers in cell and developmental biology · 2022Review
- Targeted delivery of nanomedicines for promoting vascular regeneration in ischemic diseases.Theranostics · 2022Review
- GαJournal of immunology (Baltimore, Md. : 1950) · 2021Article
- Targeting GαNature communications · 2021Article
- Shear and Integrin Outside-In Signaling Activate NADPH-Oxidase 2 to Promote Platelet Activation.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 2 institutions in 1 country.
Aiming PangDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-3706-3139
Ni ChengDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-9013-690X
Yujie CuiDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-9466-9853
Yanyan BaiDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Zhigang HongDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-7012-1770
M Keegan DelaneyDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-1534-7843
Yaping ZhangDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Claire ChangDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Can WangDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-2665-0269
Chang LiuDepartment of Chemical Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0001-5271-9867
Paola Leon PlataDepartment of Chemical Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-5575-5334
Alexander ZakharovDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Kasim KabirovDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Jalees RehmanDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-2787-9292
Randal A SkidgelDupage Medical Technology Inc., Willowbrook, IL 60527, USA.ORCID 0000-0002-7611-5053
Asrar B MalikDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Ying LiuDepartment of Chemical Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-1207-8409
Aleksander LyubimovDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Minyi GuDupage Medical Technology Inc., Willowbrook, IL 60527, USA.
Xiaoping DuDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA. xdu@uic.edu.ORCID 0000-0001-9842-8192
University of Illinois Chicago · USDuPage Medical Group · US
Funding
TRPC6 Regulation of Lung Endothelial Barrier FunctionP01HL060678 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MALIK, ASRAR B. · 2000 to 2020
$40.1MTrpm2 Regulation of Phagocyte Bactericidal Activity and Resolution of Lung InjuryP01HL077806 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MALIK, ASRAR B. · 2005 to 2019
$27.0MTHROMBIN-INDUCED PULMONARY VASCULAR PERMEABILITYR01HL045638 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KOMAROVA, YULIA A · 1991 to 2025
$12.0MMechanisms of integrin signaling and a new anti-platelet/anti-inflammatory approachR35HL150797 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Xiaoping Du · 2020 to 2026
$6.8MSignaling mechanisms of platelet GPIb-IXR01HL062350 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DU, XIAOPING · 2000 to 2017
$6.0MOutside-in signaling mechanisms of platelet integrin alpha-llb-beta3R01HL080264 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DU, XIAOPING · 2007 to 2019
$4.6MNew Strategies for Treating Septic Vasculopathy Inflammation and ThrombosisR01HL125356 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BONINI, MARCELO G., DU, XIAOPING · 2014 to 2018
$3.4MIntegration Free IPS Cells-Derived Progenitors for Cardiac RegenerationR01HL126516 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI REHMAN, JALEES · 2015 to 2019
$3.0MTargeting integrin outside-in signaling for treating sepsisR43HL142396 · NHLBI · DUPAGE MEDICAL TECHNOLOGY, INC. · PI DELANEY, MICHAEL KEEGAN, SKIDGEL, RANDAL A · 2018 to 2018
$225kNHLBI NIH HHS HHSN268201400007CNHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS P01 HL060678NHLBI NIH HHS P01 HL077806NHLBI NIH HHS R01 HL045638NHLBI NIH HHS R01 HL062350NHLBI NIH HHS R01 HL080264NHLBI NIH HHS R01 HL125356NHLBI NIH HHS R01 HL126516NHLBI NIH HHS R35 HL150797NHLBI NIH HHS R43 HL142396
Abstract
Inefficient delivery is a major obstacle to the development of peptide-based drugs targeting the intracellular compartment. We recently showed that selectively inhibiting integrin outside-in signaling using a peptide (mP6) derived from the Gα
Indexed as
Myocardial Reperfusion InjuryNanoparticlesPharmaceutical PreparationsThrombosisAnimalsIschemiaMicePeptidesPeptidesPharmaceutical Preparations
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.