Evidence map›Paper›PMID 32669422›Full record

ArticleScience translational medicine2020

Two-miRNA-based finger-stick assay for estimation of absorbed ionizing radiation dose.

Marshleen Yadav, Sagar Bhayana, Joseph Liu, Lanchun Lu, Jason Huang, Ya Ma, Zahida Qamri, Xiaokui Mo, Diviya S Jacob, Shashaank T Parasa and 5 more

Open access · greenAbstract read
In one paragraph

Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
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  12. Biomarkers to Predict Lethal Radiation Injury to the Rat Lung.International journal of molecular sciences · 2023
    Article
  13. Review
  14. Review
  15. Transcriptomics for radiation biodosimetry: progress and challenges.International journal of radiation biology · 2023
    Review
  16. Review
  17. Article
  18. Review
  19. MicroRNAs as Biomarkers for Ionizing Radiation Injury.Frontiers in cell and developmental biology · 2022
    Review
  20. The transcriptomic revolution and radiation biology.International journal of radiation biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Marshleen YadavThe Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.ORCID 0000-0002-4778-8347
Sagar BhayanaThe Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.ORCID 0000-0002-6050-3596
Joseph LiuThe Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Lanchun LuThe Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.ORCID 0000-0003-2932-0852
Jason HuangThe Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Ya MaThe Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.ORCID 0000-0003-4843-4759
Zahida QamriThe Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.ORCID 0000-0003-4841-8337
Xiaokui MoCenter for Biostatistics, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-9797-2687
Diviya S JacobThe Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Shashaank T ParasaThe Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Noureen BhuiyaThe Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.ORCID 0000-0001-8708-6553
Paolo FaddaThe Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.ORCID 0000-0001-9444-1461
Meng Xu-WelliverThe Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.ORCID 0000-0002-8747-692X
Arnab ChakravartiThe Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Naduparambil K JacobThe Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA. naduparambil.jacob@osumc.edu.ORCID 0000-0002-4056-2863
The Ohio State University · USThe Ohio State University Wexner Medical Center · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
NCI NIH HHS P30 CA016058Shared Services Center NASA 80NSSC18K1691
6 · The paper itself

Abstract

Nuclear radiation and radioactive fallouts resulting from a nuclear weapon detonation or reactor accidents could result in injuries affecting multiple sensitive organs, defined as acute radiation syndrome (ARS). Rapid and early estimation of injuries to sensitive organs using markers of radiation response is critical for identifying individuals who could potentially exhibit ARS; however, there are currently no biodosimetry assays approved for human use. We developed a sensitive microRNA (miRNA)-based blood test for radiation dose reconstruction with ±0.5 Gy resolution at critical dose range. Radiation dose-dependent changes in

Indexed as

MicroRNAsAnimalsBiological AssayBiomarkersDose-Response Relationship, RadiationHumansMiceRadiation DosageRadiation, IonizingBiomarkersMicroRNAs

Identifiers

PMID32669422
PMCPMC8501214
OpenAlexW3042665126

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.