ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
The Mesolimbic Dopamine Activity Signatures of Relapse to Alcohol-Seeking.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Article
- Functional bipartition of medial prefrontal cortex into salience detection and movement gain.bioRxiv : the preprint server for biology · 2026Article
- Renewal and reacquisition of substance-associated relapse.Frontiers in psychology · 2026Review
- The mesocorticolimbic system in stimulant use disorder.Molecular psychiatry · 2025Review
- Progress toward Multianalyte Neurochemical Detection: Techniques and Applications.ACS chemical neuroscience · 2025Review
- White matter neural substrates in alcohol dependence with genetic risk and their role in pathological reward process.Scientific reports · 2025Article
- Fiber Photometry Analysis of Spontaneous Dopamine Signals: TheACS chemical neuroscience · 2025Article
- Kappa opioid receptors diminish spontaneous dopamine signals in awake mice through multiple mechanisms.Neuropharmacology · 2025Article
- Obtaining artifact-corrected signals in fiber photometry via isosbestic signals, robust regression, and dF/F calculations.Neurophotonics · 2025Article
- Fiber photometry analysis of spontaneous dopamine signals: The z-scored data are not the data.bioRxiv : the preprint server for biology · 2025Article
- Neurospirituality Connectome - Role in Neurology and Reward Deficiency Syndrome (RDS).Neurology (E-Cronicon) · 2025Article
- Article
- Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning.Current biology : CB · 2024Article
- Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving.bioRxiv : the preprint server for biology · 2024Article
- Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning.bioRxiv : the preprint server for biology · 2024Article
- Nucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure.Nature communications · 2024Article
- A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging.Neuropharmacology · 2024Article
- Kappa Opioid Receptors Negatively Regulate Real Time Spontaneous Dopamine Signals by Reducing Release and Increasing Uptake.bioRxiv : the preprint server for biology · 2024Article
- The nucleus accumbens in reward and aversion processing: insights and implications.Frontiers in behavioral neuroscience · 2024Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mesolimbic dopamine system comprises distinct compartments supporting different functions in learning and motivation. Less well understood is how complex addiction-related behaviors emerge from activity patterns across these compartments. Here we show how different forms of relapse to alcohol-seeking in male rats are assembled from activity across the VTA and the nucleus accumbens. First, we used chemogenetic approaches to show a causal role for VTA TH neurons in two forms of relapse to alcohol-seeking: renewal (context-induced reinstatement) and reacquisition. Then, using gCaMP fiber photometry of VTA TH neurons, we identified medial and lateral VTA TH neuron activity profiles during self-administration, renewal, and reacquisition. Next, we used optogenetic inhibition of VTA TH neurons to show distinct causal roles for VTA subregions in distinct forms of relapse. We then used dLight fiber photometry to measure dopamine binding across the ventral striatum (medial accumbens shell, accumbens core, lateral accumbens shell) and showed complex and heterogeneous profiles of dopamine binding during self-administration and relapse. Finally, we used representational similarity analysis to identify mesolimbic dopamine signatures of self-administration, extinction, and relapse. Our results show that signatures of relapse can be identified from heterogeneous activity profiles across the mesolimbic dopamine system and that these signatures are unique for different forms of relapse.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.