Evidence map›Paper›PMID 32669326›Full record

ArticleJournal of virology2020

Nonhuman Primate Testing of the Impact of Different Regulatory T Cell Depletion Strategies on Reactivation and Clearance of Latent Simian Immunodeficiency Virus.

Ranjit Sivanandham, Adam J Kleinman, Paola Sette, Egidio Brocca-Cofano, Sindhuja Murali Kilapandal Venkatraman, Benjamin B Policicchio, Tianyu He, Cuiling Xu, Julia Swarthout, Zhirui Wang and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. The Hitchhiker Guide to CD4Frontiers in immunology · 2021
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ranjit SivanandhamDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-7431-8415
Adam J KleinmanDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Paola SetteDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Egidio Brocca-CofanoDepartment of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Sindhuja Murali Kilapandal VenkatramanDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Benjamin B PolicicchioDepartment of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Tianyu HeDepartment of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Cuiling XuDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Julia SwarthoutDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Zhirui WangDepartment of Surgery, School of Medicine, University of Colorado, Aurora, Colorado, USA.
Ivona PandreaDepartment of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Cristian ApetreiDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA apetreic@pitt.edu.ORCID 0000-0002-0322-7185
University of Pittsburgh · USUniversity of Colorado Anschutz Medical Campus · US

Funding

SIV Pathogenesis in African Green Monkeys and Pigtailed MacaquesR01HL117715 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VASILE PANDREA, IVONA · 2012 to 2021
$7.0M
Interventions to Reduce Hypercoagulability in Old SIV-Infected NHPsR01HL123096 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VASILE PANDREA, IVONA · 2015 to 2025
$6.8M
Assessing the Role of GI Tract Dysfunction to HIV/SIV Disease ProgressionR01DK113919 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CRISTIAN APETREI, Ivona Vasile-Pandrea · 2017 to 2026
$5.7M
Immunology of Infectious DiseaseT32AI060525 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JoAnne L. Flynn · 2005 to 2026
$5.3M
New Strategy to Improve Gastrointestinal Health in SIV/HIVR01DK119936 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APETREI, CRISTIAN · 2018 to 2022
$5.1M
Animal Model for Testing SIV Latency Reversal StrategiesR01AI119346 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APETREI, CRISTIAN · 2015 to 2019
$3.4M
PITT AIDS RESEARCH TRAINING PROGRAMT32AI065380 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BARRATT-BOYES, SIMON M · 2005 to 2020
$3.2M
NHLBI NIH HHS R01 HL117715NHLBI NIH HHS R01 HL123096NIAID NIH HHS R01 AI119346NIAID NIH HHS T32 AI060525NIAID NIH HHS T32 AI065380NIDDK NIH HHS R01 DK113919NIDDK NIH HHS R01 DK119936
6 · The paper itself

Abstract

Regulatory T cells (Tregs) may be key contributors to the HIV/SIV latent reservoir, since they harbor high levels of HIV/SIV; reverse CD4

Indexed as

AnimalsAnti-Retroviral AgentsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytokinesDiphtheria ToxinImmunity, CellularInflammationInterleukin-2Interleukin-2 Receptor alpha SubunitLymphopeniaMacaca mulattaPrimatesReceptors, CCR4Recombinant Fusion ProteinsSimian Immunodeficiency VirusAnti-Retroviral AgentsCytokinesDiphtheria ToxinInterleukin-2interleukin 2-diphtheria toxinInterleukin-2 Receptor alpha SubunitReceptors, CCR4Recombinant Fusion ProteinsCCR4CD25denileukin diftitoxHIVHIV curehuman immunodeficiency virusIL-2immunotoxinlatency reversal agentLRAOntakregulatory T cellshock and killsimian immunodeficiency virusSIVTreg

Identifiers

PMID32669326
PMCPMC7495362
OpenAlexW3042721821

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.