Evidence map›Paper›PMID 32669265›Full record

ArticleAntimicrobial agents and chemotherapy2020

Discovery of M Protease Inhibitors Encoded by SARS-CoV-2.

Hui-Chen Hung, Yi-Yu Ke, Sheng Yu Huang, Peng-Nien Huang, Yu-An Kung, Teng-Yuan Chang, Kuei-Jung Yen, Tzu-Ting Peng, Shao-En Chang, Chin-Ting Huang and 9 more

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
2.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 110 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. SARS-CoV-2 MSLAS discovery : advancing life sciences R & D · 2024
    Article
  8. Review
  9. Consensus Pharmacophore Strategy For Identifying Novel SARS-Cov-2 MJournal of chemical information and modeling · 2024
    Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Discovery of PLACS omega · 2023
    Article
  15. Article
  16. Article
  17. The Potential of Stilbene Compounds to Inhibit MCurrent issues in molecular biology · 2022
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Hui-Chen HungInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.
Yi-Yu KeInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.
Sheng Yu HuangResearch Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan.
Peng-Nien HuangResearch Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan.
Yu-An KungResearch Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan.
Teng-Yuan ChangInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.
Kuei-Jung YenInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.
Tzu-Ting PengDepartment of Animal Technology Laboratories, Agricultural Technology Research Institute (ATRI), Miaoli, Taiwan.
Shao-En ChangInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.
Chin-Ting HuangInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.
Ya-Ru TsaiInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.
Szu-Huei WuInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.
Shiow-Ju LeeInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.
Jiunn-Horng LinDepartment of Animal Technology Laboratories, Agricultural Technology Research Institute (ATRI), Miaoli, Taiwan.
Bing-Sin LiuNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.
Wang-Chou SungNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.
Shin-Ru Shih *Research Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan srshih@mail.cgu.edu.tw ctchen@nhri.edu.tw tsuanhsu@nhri.edu.tw.ORCID 0000-0003-4874-401X
Chiung-Tong Chen *Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan srshih@mail.cgu.edu.tw ctchen@nhri.edu.tw tsuanhsu@nhri.edu.tw.
John Tsu-An Hsu *Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan srshih@mail.cgu.edu.tw ctchen@nhri.edu.tw tsuanhsu@nhri.edu.tw.ORCID 0000-0002-8766-8681
National Health Research Institutes · TWChang Gung University · TWAgricultural Technology Research Institute · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus (CoV) disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is a health threat worldwide. Viral main protease (M

Indexed as

Amino Acid MotifsAnimalsAntiviral AgentsBetacoronavirusCatalytic DomainChlorocebus aethiopsCoronavirus 3C ProteasesCysteine EndopeptidasesGene ExpressionLactamsLeucineMolecular Docking SimulationProtease InhibitorsProtein BindingProtein Conformation, alpha-HelicalProtein Conformation, beta-StrandAntiviral AgentsCoronavirus 3C ProteasesCysteine EndopeptidasesGC376LactamsLeucineProtease InhibitorsPyrrolidinesRecombinant ProteinsSulfonic AcidsViral Nonstructural Proteinsantiviral researchCOVID-19GC376MproM proteaseSARS-CoV-2

Identifiers

PMID32669265
PMCPMC7449189
OpenAlexW3043740782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.