ArticleReproductive biology and endocrinology : RB&E2020
Does the sex ratio of singleton births after frozen single blastocyst transfer differ in relation to blastocyst development?
Article in Reproductive biology and endocrinology : RB&E, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Maternal serum progesterone and BMI are associated with neonatal sex ratios following single frozen embryo transfer.PloS one · 2026Article
- The association of embryo developmental rate and morphological grading with neonatal sex ratio.Scientific reports · 2025Article
- Effect of blastocyst quality on neonatal outcomes in frozen embryo transfer cycles: a cohort study.Journal of assisted reproduction and genetics · 2025Article
- Inner Cell Mass Grade and Earlier Blastulation Are Associated with Pregnancy Outcomes in Euploid Embryos.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- The Effect of Assisted Reproductive Technologies on Human Sex Ratios.The Australian & New Zealand journal of obstetrics & gynaecology · 2025Article
- Predictive Ability of an Objective and Time-Saving Blastocyst Scoring Model on Live Birth.Biomedicines · 2025Article
- Comparative analysis of cumulative live birth rates in patients with recurrent pregnancy loss undergoing preimplantation genetic testing for aneuploidy versus conventional in vitro fertilisation/intracytoplasmic sperm injection: a retrospective study.Journal of ovarian research · 2025Article
- Effects of Various Transfer Strategies of Frozen-Thawed Cleavage-Stage and Blastocyst Embryos on Pregnancy and Neonatal Outcomes in Different Age Groups.Journal of multidisciplinary healthcare · 2025Article
- Article
- Culture media affect sex after IVF treatment-a detailed analysis of explanatory variables.Journal of assisted reproduction and genetics · 2024Article
- Sex ratio shift after frozen single blastocyst transfer in relation to blastocyst morphology parameters.Scientific reports · 2024Article
- Improved pregnancy rate and sex ratio in fresh/frozenJournal of animal science and technology · 2023Article
- Effect of development speed and quality of blastocyst on singleton birthweight in single frozen-thawed blastocyst transfer cycles.Frontiers in endocrinology · 2023Article
- Diagnostic value of a single β-hCG test in predicting reproductive outcomes in women undergoing cleavage embryo transfer: a retrospective analysis from a single center.Reproductive health · 2022Article
- Article
- Perinatal outcomes of singleton live births after late moderate-to-severe ovarian hyperstimulation syndrome: A propensity score-matched study.Frontiers in endocrinology · 2022Article
- Blastocyst quality and perinatal outcomes of frozen-thawed single blastocyst transfer cycles.Frontiers in endocrinology · 2022Article
- Optimal waiting period for frozen embryo transfer after hysteroscopic polypectomy: A propensity score matching analysis.Frontiers in endocrinology · 2022Article
- Embryo quality, ploidy, and transfer outcomes in male versus female blastocysts.Journal of assisted reproduction and genetics · 2021Article
- History of Recurrent Implantation Failure is Associated With the Incidence of Adverse Perinatal Outcomes in Singleton Live Births Following Frozen-Thawed Embryo Transfer Cycles.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate the associations between blastocyst development and the sex ratio (male:female) among singleton live births resulting from single-blastocyst frozen embryo transfer (FET) cycles.
methodsPatients with singleton live births following the first autologous single FET of non- preimplantation genetic testing (PGT) blastocysts in a single reproductive medicine department between January 2015 and February 2019 were included in this retrospective study. The primary outcome measure was the singleton sex ratio. Multivariable logistic regression models were used to estimate the associations between blastocyst quality and singleton sex ratio after adjustment for some potential confounders.
resultsThere were 638 high-quality and 572 poor-quality single blastocyst FETs, and the blastocysts were conceived via 855 IVF and 355 ICSI treatments. A total of 1210 singleton live births were assessed. High-quality single blastocyst FET resulted in a significantly higher sex ratio than did poor-quality single blastocyst FET (60% vs. 49.7%, P < 0.001). The infertility cause was not associated with sex ratio among singleton live births (P = 0.537). The results of a multivariate analysis revealed that a high-quality blastocyst has a 150% higher probability of being male than a poor-quality blastocyst (adjusted odds ratio (aOR) 1.57; 95% CI 1.24-2, P < 0.001). Among the three blastocyst morphological parameters, Grade B trophectoderm was significantly associated with a higher sex ratio than Grade C (aOR 1.71; 95% CI 1.33-2.21. P < 0.001). Neither expansion degree nor inner cell mass degree were significantly associated with the singleton sex ratio.
conclusionsA single high-quality blastocyst FET has a higher chance of resulting in a male infant than a female infant. The results demonstrate that grade B trophectoderm confers benefits in improving the implantation potential of male blastocysts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.