Evidence map›Paper›PMID 32669023›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

D-Glucose uptake and clearance in the tauopathy Alzheimer's disease mouse brain detected by on-resonance variable delay multiple pulse MRI.

Lin Chen, Zhiliang Wei, Kannie Wy Chan, Yuguo Li, Kapil Suchal, Sheng Bi, Jianpan Huang, Xiang Xu, Philip C Wong, Hanzhang Lu and 3 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Dynamic glucose-enhanced MRI in brain tumors.Magma (New York, N.Y.) · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Lower GLUT1 and unchanged MCT1 in Alzheimer's disease cerebrovasculature.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. In vivo methods for imaging blood-brain barrier function and dysfunction.European journal of nuclear medicine and molecular imaging · 2023
    Review
  17. Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  18. Article
  19. Characterizing region-specific glucose metabolic profile of the rodent brain using Seahorse XFe96 analyzer.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lin ChenF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA.ORCID 0000-0003-0108-4309
Zhiliang WeiF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA.
Kannie Wy ChanRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yuguo LiF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA.
Kapil SuchalDepartment of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sheng BiDepartment of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-2441-0528
Jianpan HuangDepartment of Biomedical Engineering, City University of Hong Kong, Hong Kong, China.
Xiang XuF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA.
Philip C WongDepartment of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hanzhang LuF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA.
Peter Cm van ZijlF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA.
Tong LiDepartment of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jiadi XuF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA.

Funding

'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S. · 1985 to 2019
$37.6M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2020 to 2026
$29.3M
Development and Translation of D-glucose as a Diagnostic Agent for MRI of CancerR01EB019934 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2015 to 2019
$5.7M
Dorsomedial Hypothalamic Signaling Pathways and Energy BalanceR01DK104867 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI BI, SHENG · 2016 to 2019
$1.9M
Development and Translation of D-glucose as an MRI Contrast Agent for Multiple SclerosisR00EB026312 · NIBIB · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI XU, XIANG · 2020 to 2022
$747k
Imaging brain glucose uptake by onVDMP MRI in Huntington's DiseaseR21NS118079 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DUAN, WENZHEN, XU, JIADI · 2020 to 2020
$465k
Impaired Cerebral Glucose Uptake in the Brain as an MRI Marker for Alzheimer' s DiseaseR21AG065794 · NIA · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI XU, JIADI · 2020 to 2020
$446k
Development and Translation of D-glucose as an MRI Contrast Agent for Multiple SclerosisK99EB026312 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI XU, XIANG · 2018 to 2020
$242k
Defining the Ischemic Penumbra by pH Mapping in Acute IschemiaR03NS109664 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI XU, JIADI · 2018 to 2019
$162k
NIA NIH HHS P30 AG066507NIA NIH HHS P50 AG005146NIA NIH HHS R21 AG065794NIBIB NIH HHS K99 EB026312NIBIB NIH HHS R00 EB026312NIBIB NIH HHS R01 EB019934NIDDK NIH HHS R01 DK104867NINDS NIH HHS R03 NS109664NINDS NIH HHS R21 NS118079
6 · The paper itself

Abstract

In this study, we applied on-resonance variable delay multiple pulse (onVDMP) MRI to study D-glucose uptake in a mouse model of Alzheimer's disease (AD) tauopathy and demonstrated its feasibility in discriminating AD mice from wild-type mice. The D-glucose uptake in the cortex of AD mice (1.70 ± 1.33%) was significantly reduced compared to that of wild-type mice (5.42 ± 0.70%,

Indexed as

Alzheimer DiseaseAnimalsBlood-Brain BarrierBrainCarbohydrate Metabolism, Inborn ErrorsCost-Benefit AnalysisDisease Models, AnimalFeasibility StudiesFemaleGlucoseGlymphatic SystemMagnetic Resonance ImagingMiceMice, Inbred BALB CMice, Inbred C57BLMonosaccharide Transport ProteinsGlucoseMonosaccharide Transport Proteinstau ProteinsAlzheimer’s diseaseschemical exchange saturation transferdynamic glucose enhancedGlucose uptakeon-resonance variable delay multiple pulsetau pathology

Identifiers

PMID32669023
PMCPMC8054725

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.