ReviewNutrients2020
Relevance of Essential Trace Elements in Nutrition and Drinking Water for Human Health and Autoimmune Disease Risk.
Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07109778 (Impact of Copper to Zinc Ratio on Outcome of End Stage Renal Disease Patients), which is not on this map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Copper to Zinc Ratio on Outcome of End Stage Renal Disease Patients
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 153 citations in OpenAlex.
- Essential Trace Element Status in Systemic Lupus Erythematosus: a Meta-analysis Based on Case-Control Studies.Biological trace element research · 2023Pooled it
- Circulating trace elements status in COVID-19 disease: A meta-analysis.Frontiers in nutrition · 2022Pooled it
- Assessment of Health Risk from Aconiti Kusnezoffii Radix to its Processed Products and Origin Traceability Through Inorganic Element Analysis.Biological trace element research · 2026Article
- Trace Elements in the Pancreas: From Physiological Homeostasis to the Pathogenesis of Diabetes, Pancreatitis, and Cancer-A Review.Life (Basel, Switzerland) · 2026Review
- Associations of metals and micronutrients with functional disability in Chinese older adults: a mixture analysis approach.Scientific reports · 2026Article
- Trace Elements and Viral Infectious Diseases: Dual Roles in Pathogenesis and Immunity.Infectious disease reports · 2026Review
- Essential Trace Elements in Edible Plants: Balancing Nutritional Benefits and Potential Health Risks.Journal of agricultural and food chemistry · 2026Article
- Content and Dietary Contribution Assessment of Mineral Elements in Dairy from Henan Province of China.Foods (Basel, Switzerland) · 2026Article
- The Potential Role of Iron Homeostasis and Ferroptosis in Exercise Nutrition and Health.Nutrients · 2026Review
- Role of Copper Homeostasis and Cuproptosis in Cardiovascular Disease: Molecular Insights and Metabolic Perspectives.International journal of biological sciences · 2026Review
- Screening of probiotics for promoting mineral absorption based onFrontiers in microbiology · 2026Article
- Dietary Exposure and Health Risk Assessment of Selected Toxic and Essential Metals in Various Flavored Dairy Products.Biological trace element research · 2026Article
- Modulation of the PD-1/PD-L1 axis and tumor immunity by metals and metalloids: mechanistic insights and human health implications.Frontiers in immunology · 2026Review
- Excess copper exposure and male reproductive toxicity: molecular mechanisms and potential interventions.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Review
- The clinical implications of zinc and copper levels in COPD patients: a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Metallomic characterization of induced periapical lesions-In vivo study.International endodontic journal · 2025Article
- Safety Considerations of Trace Metals in Locally Produced Nutritive Food-Drinks Consumed in Yenagoa Metropolis, Nigeria.Biological trace element research · 2025Article
- Genotoxic Effects of Chromium(III) and Cobalt(II) and Their Mixtures on the Selected Cell Lines.International journal of molecular sciences · 2025Article
- Article
- Free radicals and their impact on health and antioxidant defenses: a review.Cell death discovery · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Trace elements produce double-edged effects on the lives of animals and particularly of humans. On one hand, these elements represent potentially toxic agents; on the other hand, they are essentially needed to support growth and development and confer protection against disease. Certain trace elements and metals are particularly involved in humoral and cellular immune responses, playing the roles of cofactors for essential enzymes and antioxidant molecules. The amount taken up and the accumulation in human tissues decisively control whether the exerted effects are toxic or beneficial. For these reasons, there is an urgent need to re-consider, harmonize and update current legislative regulations regarding the concentrations of trace elements in food and in drinking water. This review aims to provide information on the interrelation of certain trace elements with risk of autoimmune disease, with a particular focus on type 1 diabetes and multiple sclerosis. In addition, an overview of the current regulations and regulatory gaps is provided in order to highlight the importance of this issue for everyday nutrition and human health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.