Evidence map›Paper›PMID 32668312›Full record

ArticleEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences2020

A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection.

Yasmin Abo-Zeid, Nasser S M Ismail, Gary R McLean, Nadia M Hamdy

Open access · greenAbstract read
In one paragraph

Article in European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed
4.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 235 citations in OpenAlex.

  1. Article
  2. Advances in the application of molecular docking in nanomedicine.Journal of computer-aided molecular design · 2026
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  16. Smart stimuli-responsive drug delivery systems in spotlight of COVID-19.Asian journal of pharmaceutical sciences · 2023
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Yasmin Abo-ZeidPharmaceutics Dept., Faculty of Pharmacy, Helwan University, Cairo, Egypt. Electronic address: yasmin.abozeid@pharm.helwan.edu.eg.
Nasser S M IsmailPharmaceutical Chemistry Dept., Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, Cairo 12311, Egypt. Electronic address: nasser.saad@fue.edu.eg.
Gary R McLeanCellular and Molecular Immunology Research Centre, London Metropolitan University, 166-220 Holloway Road, London, N7 8DB, UK; National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG UK. Electronic address: g.mclean@londonmet.ac.uk.
Nadia M HamdyBiochemistry Dept., Faculty of Pharmacy, Ain shams University, Cairo, 11566, Egypt. Electronic address: nadia_hamdy@pharma.asu.edu.eg.
Ain Shams University · EGFuture University in Egypt · EGHelwan University · EGLondon Metropolitan University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19, is a disease resulting from the SARS-CoV-2 global pandemic. Due to the current global emergency and the length of time required to develop specific antiviral agent(s) and a vaccine for SARS-CoV-2, the world health organization (WHO) adopted the strategy of repurposing existing medications to treat COVID-19. Iron oxide nanoparticles (IONPs) were previously approved by the US food and drug administration (FDA) for anemia treatment and studies have also demonstrated its antiviral activity in vitro. Therefore, we performed a docking study to explore the interaction of IONPs (Fe

Indexed as

Molecular Docking SimulationCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentDrug ApprovalDrug RepositioningFerric CompoundsHumansMetal NanoparticlesPandemicsPneumonia, ViralProtein ConformationSpike Glycoprotein, CoronavirusUnited StatesUnited States Food and Drug AdministrationViral Envelope ProteinsE1 protein, Hepatitis C virusFerric Compoundsferric oxideglycoprotein E2, Hepatitis C virusSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Viral Envelope ProteinsCovid-19Hcv glycoproteins E1 and E2Iron oxide nanoparticles (IONPs)Molecular dockingReactive oxygen species (ROS)Repurposing medicationSars-CoV-2

Identifiers

PMID32668312
PMCPMC7354764
OpenAlexW3041042540

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.