ArticleCell reports2020
CD4
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Peptide Thioester and Triazole Derivatives Through On-Resin Dual-Modification of Peptide Thiosulfonates.Angewandte Chemie (International ed. in English) · 2026Article
- Shared CD4+ T cell receptor specificity groups in Crohn's disease and ulcerative colitis.JCI insight · 2026Article
- In vivo engineering tumor cells to a universal "all-in-one" cancer vaccine with full antigen spectrum.Science advances · 2026Article
- T-cell-mediated immunity to influenza A (H2N3): implications for caccine efficacy and cross-subtype protection.Archives of microbiology · 2026Review
- HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Gold Nanoparticles as a Platform for Delivery of Immunogenic Peptides to THP-1 Derived Macrophages: Insights into Nanotoxicity.Vaccines · 2025Article
- Deep exploration of the TCR CDR3β repertoire specific for viral CD4 T-cell epitopes inside the circulating T-cell repertoire.Frontiers in immunology · 2025Article
- Promiscuous class II-binding SARS-CoV-2-nuc derived vaccine-peptide induced extensive conventional, innate and unconventional T cell responses.Frontiers in immunology · 2025Article
- Adjuvant-free, self-assembling ferritin nanoparticle vaccine coupled with influenza virus hemagglutinin protein carrying M1 and PADRE epitopes elicits cross-protective immune responses.Frontiers in immunology · 2025Article
- Polyanhydride nanovaccine against H3N2 influenza A virus generates mucosal resident and systemic immunity promoting protection.NPJ vaccines · 2024Article
- Historical perspective and future directions: computational science in immuno-oncology.Journal for immunotherapy of cancer · 2024Review
- Immuno-informatics study identifies conserved T cell epitopes in non-structural proteins of Bluetongue virus serotypes: formulation of a computationally optimized next-generation broad-spectrum multi-epitope vaccine.Frontiers in immunology · 2024Article
- Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4Cell reports · 2023Article
- Transcriptome Analysis Reveals the Immunoregulatory Activity of Rice Seed-Derived Peptide PEP1 on Dendritic Cells.Molecules (Basel, Switzerland) · 2023Article
- Loading dynamics of one SARS-CoV-2-derived peptide into MHC-II revealed by kinetic models.Biophysical journal · 2023Article
- Connection between MHC class II binding and aggregation propensity: The antigenic peptide 10 ofComputational and structural biotechnology journal · 2023Article
- Anti-tumor memory CD4 and CD8 T-cells quantified by bulk T-cell receptor (TCR) clonal analysis.Frontiers in immunology · 2023Article
- HLA-dependent variation in SARS-CoV-2 CD8Immunology · 2022Article
- Article
- The Many Faces of CD4International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 4 institutions in 4 countries.
Alexander Greenshields-WatsonCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Meriem AttafCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Bruce J MacLachlanCardiff University, School of Medicine, Heath Park, Cardiff, UK; Monash Biomedicine Discovery Institute, 19 Innovation Walk, Clayton, Victoria 3800, Australia.
Thomas WhalleyCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Cristina RiusCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Aaron WallCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Angharad LloydCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Hywel HughesCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Kathryn E StrangeCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Georgina H MasonCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Andrea J SchauenburgCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Sarah L Hulin-CurtisCardiff University, School of Medicine, Heath Park, Cardiff, UK.
James GearyCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Yuan ChenCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Sarah N LauderCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Kathryn SmartCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Dhanasekaran VijaykrishnaMonash Biomedicine Discovery Institute, 19 Innovation Walk, Clayton, Victoria 3800, Australia.
Miguel L GrauMonash Biomedicine Discovery Institute, 19 Innovation Walk, Clayton, Victoria 3800, Australia.
Mikhail ShugayCenter of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia.
Robert AndrewsCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Garry DoltonCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Pierre J RizkallahCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Awen M GallimoreCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Andrew K SewellCardiff University, School of Medicine, Heath Park, Cardiff, UK.
Andrew J GodkinCardiff University, School of Medicine, Heath Park, Cardiff, UK; Department of Gastroenterology, Hepatology and Endoscopy, University Hospital of Wales, Cardiff, UK. Electronic address: godkinaj@cardiff.ac.uk.
David K ColeCardiff University, School of Medicine, Heath Park, Cardiff, UK. Electronic address: coledk@cardiff.ac.uk.
Cardiff University · GBAustralian Regenerative Medicine Institute · AUDiscovery Institute · USSkolkovo Institute of Science and Technology · RU
Funding
Biotechnology and Biological Sciences Research Council BB/H001085/1Cancer Research UKNIAID NIH HHS HHSN272201400006CWellcome TrustWellcome Trust WT095767Wellcome Trust WT100327MA
Abstract
T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on CD8
Indexed as
AdultAmino Acid MotifsAmino Acid SequenceAnimalsBirdsCD4-Positive T-LymphocytesComplementarity Determining RegionsConserved SequenceEpitopesFemaleGerm CellsHLA-DR1 AntigenHumansImmunodominant EpitopesImmunoglobulin Variable RegionInfluenza A virusComplementarity Determining RegionsEpitopesHLA-DR1 AntigenImmunodominant EpitopesImmunoglobulin Variable RegionPeptidesReceptors, Antigen, T-CellViral ProteinsbiochemistryCD4 T cellsclonotypingHLA class IIimmunologyinfluenzapeptide epitopespHLA mutlimerT cell receptorX-ray crystallography
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.