ArticleCell reports2020
Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo.
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed, 1 pooled it
11.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
154 citing papers in PubMed, 1 synthesis or guideline pooled it, 243 citations in OpenAlex.
- Advances in the study of exosomes in cardiovascular diseases.Journal of advanced research · 2024Pooled it
- Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation.Circulation research · 2026Review
- Article
- RNY1 Is Heterogeneously Partitioned in Inflamed Airway Fluid and Modulates Pro-Inflammatory Macrophage Transcriptional Programming.Journal of extracellular biology · 2026Article
- The Dual Role of Exosomes in Gout: From Inflammatory Amplifiers to Therapeutic Regulators.Inflammation · 2026Review
- MicroRNAs as master regulators of macrophage function in atherosclerosis: From polarization to therapeutic potential.iScience · 2026Review
- Macrophage PSRC1 attenuates atherosclerosis via extracellular vesicle-mediated MBD2 delivery to induce PCSK9 promoter methylation in hepatocytes.Cell & bioscience · 2026Article
- Mapping the miRNA landscape of primitive macrophage extracellular vesicles highlights their pro-vasculogenic effects in engineered human cardiac tissue.APL bioengineering · 2026Article
- Review
- A review of recent advances in exosome-mediated drug delivery for regenerative therapy and immunomodulation.Biomedical engineering online · 2026Review
- Nanomedicine-based theranostics in atherosclerotic cardiovascular diseases.Journal of biomedical science · 2026Review
- Extracellular vesicles in the heart: mediators of intercellular communication in health and disease in vitro.Cell communication and signaling : CCS · 2026Review
- Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review).International journal of molecular medicine · 2026Review
- Exercise-induced effects on atherogenesis and tryptophan catabolism via the kynurenine pathway in an HIV-associated atherosclerosis mouse model.Experimental physiology · 2026Article
- Exosome-Mediated Intercellular Communication in the Pathological Processes of Gouty Arthritis and Its Treatment.International journal of molecular sciences · 2026Review
- M2 macrophage exosomes reverse heart failure post-myocardial infarction by suppressing type 1 interferon signaling in myeloid cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- High density lipoproteins and extracellular vesicles-distinct but overlapping circulating particles and their role in atherosclerosis.Frontiers in cardiovascular medicine · 2026Review
- Spatial architecture of atherosclerotic plaques: coordinating immune responses through mechanotransduction and vesicular trafficking.Frontiers in cell and developmental biology · 2026Review
- 80 years of extracellular vesicles: from discovery to clinical translation.Extracellular vesicles and circulating nucleic acids · 2026Review
- RNY1 partitions into extracellular vesicles and ribonucleoprotein particles during airway inflammation to regulate macrophage programming.bioRxiv : the preprint server for biology · 2025Article
94 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 6 institutions in 1 country.
Laura BouchareychasDepartment of Surgery, Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Northern California Institute for Research and Education, San Francisco, CA 94121, USA.
Phat DuongNorthern California Institute for Research and Education, San Francisco, CA 94121, USA.
Sergio CovarrubiasDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Eric AlsopNeurogenomics, The Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Tuan Anh PhuNorthern California Institute for Research and Education, San Francisco, CA 94121, USA.
Allen ChungNorthern California Institute for Research and Education, San Francisco, CA 94121, USA.
Michael GomesNorthern California Institute for Research and Education, San Francisco, CA 94121, USA.
David WongNorthern California Institute for Research and Education, San Francisco, CA 94121, USA.
Bessie MeechoovetNeurogenomics, The Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Allyson CapiliDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Ryo YamamotoInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Lorry I. Lokey Stem Cell Research Building, 265 Campus Drive, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Hiromitsu NakauchiInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Lorry I. Lokey Stem Cell Research Building, 265 Campus Drive, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Michael T McManusDepartment of Microbiology and Immunology, UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
Susan CarpenterDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Kendall Van Keuren-JensenNeurogenomics, The Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Robert L RaffaiDepartment of Surgery, Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Northern California Institute for Research and Education, San Francisco, CA 94121, USA; Department of Veterans Affairs, Surgical Service (112G), San Francisco VA Medical Center, San Francisco, CA 94121, USA. Electronic address: robert.raffai@ucsf.edu.
Northern California Institute for Research and Education · USTranslational Genomics Research Institute · USUniversity of California, Santa Cruz · USStanford University · USUniversity of California, San Francisco · USSan Francisco VA Medical Center · US
Funding
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8MSidTI/2-dependent EC-RNA Biogenesis and UptalceU19CA179513 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCMANUS, MICHAEL T · 2013 to 2017
$8.3MTranscellular epigenetic regulation by ex-small RNA in C. elegantU19CA179512 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BLELLOCH, ROBERT · 2013 to 2017
$7.4MUCSF Core Center for Musculoskeletal Biology and MedicineP30AR066262 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 2014 to 2018
$3.0MHyperglycemia and MicroRNA Dysregulation of Inflammation in AtherosclerosisR01HL133575 · NHLBI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI RAFFAI, ROBERT · 2016 to 2019
$1.5MP.R.I.S.M: Purification of exRNA by Immuno-capture and Sorting using MicrofluidicUH3CA241703 · NCI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MATEESCU, BOGDAN, RAFFAI, ROBERT · 2021 to 2022
$1.4MP.R.I.S.M: Purification of exRNA by Immuno-capture and Sorting using MicrofluidicUG3CA241703 · NCI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MATEESCU, BOGDAN, RAFFAI, ROBERT · 2019 to 2020
$774kExosomes in the Pathogenesis of Diabetic Atherosclerosis & its Treatment OpportunitiesI01BX003928 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI Robert Raffai · 2019 to 2026
–BLRD VA I01 BX003928NCI NIH HHS U19 CA179512NCI NIH HHS U19 CA179513NCI NIH HHS UG3 CA241703NCI NIH HHS UH3 CA241703NHLBI NIH HHS R01 HL133575NIAMS NIH HHS P30 AR066262NIDDK NIH HHS P30 DK063720
Abstract
Developing strategies that promote the resolution of vascular inflammation and atherosclerosis remains a major therapeutic challenge. Here, we show that exosomes produced by naive bone marrow-derived macrophages (BMDM-exo) contain anti-inflammatory microRNA-99a/146b/378a that are further increased in exosomes produced by BMDM polarized with IL-4 (BMDM-IL-4-exo). These exosomal microRNAs suppress inflammation by targeting NF-κB and TNF-α signaling and foster M2 polarization in recipient macrophages. Repeated infusions of BMDM-IL-4-exo into Apoe
Indexed as
AnimalsApolipoproteins EAtherosclerosisCell PolarityExosomesGene EditingHematopoiesisHumansInflammationInterleukin-4MacrophagesMice, Inbred C57BLMicroRNAsMyeloid CellsNF-kappa BSignal TransductionApolipoproteins EInterleukin-4MicroRNAsNF-kappa BTumor Necrosis Factor-alphaatherosclerosisexosomeextracellular vesiclehematopoiesisinflammationmacrophagemicroRNAmonocyte
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.