ArticleCell reports2020
Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium.
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 30 citations in OpenAlex.
- Nuclear dysfunction in aging and neurodegeneration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Single-cell Spatial Transcriptional Profiling Uncovers Heterogeneous Cellular Responses to Pathogenic Tau in a Mouse Model of Neurodegeneration.bioRxiv : the preprint server for biology · 2025Article
- Pathological Calcium Signaling in Traumatic Brain Injury and Alzheimer's Disease: From Acute Neuronal Injury to Chronic Neurodegeneration.International journal of molecular sciences · 2025Review
- Dysregulation of energy metabolism in Alzheimer's disease.Journal of neurology · 2024Review
- Cellular and pathological functions of tau.Nature reviews. Molecular cell biology · 2024Review
- Transgenic sensors reveal compartment-specific effects of aggregation-prone proteins on subcellular proteostasis during aging.Cell reports methods · 2024Article
- Drug repurposing for neurodegenerative diseases using Zebrafish behavioral profiles.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024Article
- m6A-dependent circular RNA formation mediates tau-induced neurotoxicity.bioRxiv : the preprint server for biology · 2024Article
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- Pathogenic tau-induced transposable element-derived dsRNA drives neuroinflammation.Science advances · 2023Article
- Pathogenic tau decreases nuclear tension in cultured neurons.Frontiers in aging · 2023Article
- Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies.Journal of biomedical science · 2022Article
- The CRTC-CREB axis functions as a transcriptional sensor to protect against proteotoxic stress in Drosophila.Cell death & disease · 2022Article
- Targeting tau only extracellularly is likely to be less efficacious than targeting it both intra- and extracellularly.Seminars in cell & developmental biology · 2022Review
- The prion-like transmission of tau oligomersFrontiers in aging neuroscience · 2022Review
- Non-Canonical Roles of Tau and Their Contribution to Synaptic Dysfunction.International journal of molecular sciences · 2021Review
- Looking at Alzheimer's Disease Pathogenesis from the Nuclear Side.Biomolecules · 2021Review
- Lighting Up CaCells · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Rebekah MahoneyBarshop Institute for Longevity and Aging Studies, University of Texas Health, San Antonio, San Antonio, TX, USA; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health, San Antonio, San Antonio, TX, USA; Department of Cell Systems and Anatomy, University of Texas Health, San Antonio, San Antonio, TX, USA.
Elizabeth Ochoa ThomasBarshop Institute for Longevity and Aging Studies, University of Texas Health, San Antonio, San Antonio, TX, USA; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health, San Antonio, San Antonio, TX, USA; Department of Cell Systems and Anatomy, University of Texas Health, San Antonio, San Antonio, TX, USA.
Paulino RamirezBarshop Institute for Longevity and Aging Studies, University of Texas Health, San Antonio, San Antonio, TX, USA; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health, San Antonio, San Antonio, TX, USA; Department of Cell Systems and Anatomy, University of Texas Health, San Antonio, San Antonio, TX, USA.
Henry E MillerDepartment of Cell Systems and Anatomy, University of Texas Health, San Antonio, San Antonio, TX, USA; Greehey Children's Cancer Institute, University of Texas Health, San Antonio, San Antonio, TX, USA.
Adrian BeckmannBarshop Institute for Longevity and Aging Studies, University of Texas Health, San Antonio, San Antonio, TX, USA; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health, San Antonio, San Antonio, TX, USA; Department of Cell Systems and Anatomy, University of Texas Health, San Antonio, San Antonio, TX, USA.
Gabrielle ZunigaBarshop Institute for Longevity and Aging Studies, University of Texas Health, San Antonio, San Antonio, TX, USA; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health, San Antonio, San Antonio, TX, USA; Department of Cell Systems and Anatomy, University of Texas Health, San Antonio, San Antonio, TX, USA.
Radek DobrowolskiGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health, San Antonio, San Antonio, TX, USA; Rutgers University, Newark, NJ, USA.
Bess FrostBarshop Institute for Longevity and Aging Studies, University of Texas Health, San Antonio, San Antonio, TX, USA; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health, San Antonio, San Antonio, TX, USA; Department of Cell Systems and Anatomy, University of Texas Health, San Antonio, San Antonio, TX, USA. Electronic address: bfrost@uthscsa.edu.
The University of Texas Health Science Center at San Antonio · USRutgers, The State University of New Jersey · US
Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1MTRAINING GRANT ON THE BIOLOGY OF AGINGT32AG021890 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Erzsebet Kokovay, JAMES FLOYD NELSON · 2003 to 2026
$11.4MSan Antonio Biomedical Education and ResearchK12GM111726 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LECHLEITER, JAMES D, OYAJOBI, BABATUNDE OLUKAYODE · 2015 to 2024
$7.6MRegulation of Neuronal Clearance Pathways via Nuclear Calcium Signaling in Alzheimer's DiseaseR01AG062475 · NIA · RUTGERS THE STATE UNIV OF NJ NEWARK · PI FRIEDMAN, WILMA J · 2019 to 2023
$2.3MNRSA Training Core (TL1)TL1TR002647 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CHUN, YONG-HEE PATRICIA, FREI, CHRISTOPHER R. · 2018 to 2022
$1.8MIntegrated Graduate Training Program in Neuroscience, UTHSCSAT32NS082145 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI David A Morilak · 2013 to 2026
$1.5MHigh Throughput DNA Sequencer: Illumina HiSeq 3000 SequencerS10OD021805 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LAI, ZHAO · 2016 to 2016
$600kNCATS NIH HHS TL1 TR002647NCI NIH HHS P30 CA054174NIA NIH HHS R01 AG062475NIA NIH HHS T32 AG021890NIGMS NIH HHS K12 GM111726NIH HHS S10 OD021805NINDS NIH HHS T32 NS082145
Abstract
Synaptic activity-induced calcium (Ca
Indexed as
Alzheimer DiseaseAnimalsAnimals, Genetically ModifiedBrainCalciumCell NucleusCyclic AMP Response Element-Binding ProteinDrosophila melanogasterGene Expression ProfilingGene Expression RegulationInduced Pluripotent Stem CellsMembrane PotentialsNeuronsNeurotoxinstau ProteinsCalciumCyclic AMP Response Element-Binding ProteinNeurotoxinstau ProteinsAlzheimer’s diseaseBK channelscalciumCREBDrosophilaiPSC-derived neuronsneurodegenerationnucleustautauopathy
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.