Trial reportDepression and anxiety2020
Associations between resting-state functional connectivity and treatment response in a randomized clinical trial for posttraumatic stress disorder.
Trial report in Depression and anxiety, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Neural correlates of psychodynamic and non-psychodynamic therapies in different clinical populations through fMRI: A meta-analysis and systematic review.Frontiers in human neuroscience · 2022Pooled it
- Functional brain imaging in posttraumatic stress disorder: a review.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Intrinsic Functional Connectivity of Right Dorsolateral Prefrontal Cortex and Hippocampus Subregions Relates to Emotional and Sensory-Perceptual Properties of Intrusive Trauma Memories.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Brain State Dynamics in Ketamine-Induced Dissociation Resemble Those in Posttraumatic Stress Disorder.Biological psychiatry global open science · 2026Article
- Article
- Size and Topography of the Brain's Functional Networks with Psychotic Experiences, Schizophrenia, and Bipolar Disorder.Biological psychiatry global open science · 2024Article
- Functional Connectivity of the Auditory Cortex in Women With Trauma-Related Disorders Who Hear Voices.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Functional changes in neural mechanisms underlying post-traumatic stress disorder in World Trade Center responders.Translational psychiatry · 2023Article
- Circulating PACAP levels are associated with increased amygdala-default mode network resting-state connectivity in posttraumatic stress disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Posterior cingulate cortex targeted real-time fMRI neurofeedback recalibrates functional connectivity with the amygdala, posterior insula, and default-mode network in PTSD.Brain and behavior · 2023Article
- Resting-state connectivity subtype of comorbid PTSD and alcohol use disorder moderates improvement from integrated prolonged exposure therapy in Veterans.Psychological medicine · 2023Article
- Neuroscientific account of Guilt- and Shame-Driven PTSD phenotypes.European journal of psychotraumatology · 2023Article
- Pre-treatment amygdala activation and habituation predict symptom change in post-traumatic stress disorder.Frontiers in behavioral neuroscience · 2023Article
- A tale of two targets: examining the differential effects of posterior cingulate cortex- and amygdala-targeted fMRI-neurofeedback in a PTSD pilot study.Frontiers in neuroscience · 2023Article
- Involvement of the brain-heart axis in the link between PTSD and cardiovascular disease.Depression and anxiety · 2022Review
- The relationship between recent PTSD secondary to sexual assault, hippocampal volume and resting state functional connectivity in adolescent girls.Neurobiology of stress · 2022Article
- Differential mechanisms of posterior cingulate cortex downregulation and symptom decreases in posttraumatic stress disorder and healthy individuals using real-time fMRI neurofeedback.Brain and behavior · 2022Article
- Altered resting-state functional connectivity of insula in children with primary nocturnal enuresis.Frontiers in neuroscience · 2022Article
- Neural contributors to trauma resilience: a review of longitudinal neuroimaging studies.Translational psychiatry · 2021Review
- Defining focal brain stimulation targets for PTSD using neuroimaging.Depression and anxiety · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAlterations in resting-state functional connectivity (rsFC) have been reported in posttraumatic stress disorder (PTSD). Here, we examined pre- and post-treatment rsFC during a randomized clinical trial to characterize alterations and examine predictors of treatment response.
methodsSixty-four combat veterans with PTSD were randomly assigned to prolonged exposure (PE) plus placebo, sertraline plus enhanced medication management, or PE plus sertraline. Symptom assessment and resting-state functional magnetic resonance imaging (fMRI) scans occurred before and after treatment. Twenty-nine trauma-exposed combat veterans without PTSD served as a control group at intake. Seed-based and region of interest (ROI)-to-ROI connectivities, as well as an exploratory connectome-based approach were used to analyze rsFC patterns. Based on previously reported findings, analyses focused on Salience Network (SN) and Default-Mode Network (DMN).
resultsAt intake, patients with PTSD showed greater DMN-dorsal attention network (DAN) connectivity (between ventromedial prefrontal cortex and superior parietal lobule; family-wise error corrected p = .011), greater SN-DAN connectivity (between insula and middle frontal gyrus; corrected p = .003), and a negative correlation between re-experiencing symptoms and within-DMN connectivity (between posterior cingulate cortex (PCC) and middle temporal gyrus; corrected p < .001). We also found preliminary evidence for associations between rsFC and treatment response. Specifically, high responders (≥50% PTSD symptom improvement), compared with low responders, had greater SN-DMN segregation (i.e., less pre-treatment amygdala-PCC connectivity; p = .011) and lower pre-treatment global centrality (p = .042).
conclusionsOur findings suggest neural abnormalities in PTSD and may inform future research examining neural biomarkers of PTSD treatment response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.