Evidence map›Paper›PMID 32668077›Full record

ReviewJournal of veterinary internal medicine2020

Classification of myasthenia gravis and congenital myasthenic syndromes in dogs and cats.

Thomas Mignan, Mike Targett, Mark Lowrie

Open access · goldAbstract readReview
In one paragraph

Review in Journal of veterinary internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Cervical ventroflexion in cats: 86 cases (2003-2024).Journal of feline medicine and surgery · 2025
    Article
  3. Article
  4. Article
  5. Article
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  8. Article
  9. Review
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  11. Review
  12. SeronegativeVeterinary sciences · 2022
    Article
  13. Article
  14. Canine Epithelial Thymic Tumors: Outcome in 28 Dogs Treated by Surgery.Animals : an open access journal from MDPI · 2021
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Thomas MignanDovecote Veterinary Hospital, Derby, UK.ORCID https://orcid.org/0000-0002-7463-7069
Mike TargettSchool of Veterinary Medicine and Science, University of Nottingham, Leicestershire, UK.
Mark LowrieDovecote Veterinary Hospital, Derby, UK.ORCID https://orcid.org/0000-0002-4993-589X
Royal Derby Hospital · GBUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myasthenia, a syndrome of impaired neuromuscular transmission, occurs as either an acquired or congenital condition. Myasthenia gravis (MG) is an acquired autoimmune disorder with autoantibodies against the neuromuscular junction (NMJ) of skeletal muscle whereas congenital myasthenic syndromes (CMSs) are a clinically heterogeneous group of genetic disorders affecting the NMJ with a young age of onset. Both conditions are diseases for which recognition is important with regard to treatment and outcome. We review the published literature on MG and CMSs in dogs and cats, and by comparison with published classification used in humans, propose a classification system for MG and CMSs in dogs and cats. Myasthenia gravis is first classified based on focal, generalized, or acute fulminating presentation. It then is subclassified according to the autoimmune disease mechanism or seronegativity. Autoimmune disease mechanism relates to the presence or absence of a thymoma, or administration of thiourylene medication in cats. Congenital myasthenic syndromes are classified according to the affected NMJ component, the mechanism of the defect of neuromuscular transmission, the affected protein, and ultimately the mutated gene responsible. In proposing this categorization of MG and CMSs, we hope to aid recognition of the disease groups for both conditions, as well as guide treatment, refine prognosis, and provide a framework for additional studies of these conditions.

Indexed as

Cat DiseasesDog DiseasesMyasthenia GravisMyasthenic Syndromes, CongenitalAnimalsCatsDogsNeuromuscular Junctioncaninefelinemegaesophagusthymomaweakness

Identifiers

PMID32668077
PMCPMC7517852
OpenAlexW3043721504

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.