Evidence map›Paper›PMID 32667981›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021

The Immunoglobulin M-Shed Acute Phase Antigen (SAPA)-test for the Early Diagnosis of Congenital Chagas Disease in the Time of the Elimination Goal of Mother-to-Child Transmission.

Yagahira E Castro-Sesquen, Freddy Tinajeros, Caryn Bern, Gerson Galdos-Cardenas, Edith S Malaga, Edward Valencia Ayala, Kathryn Hjerrild, Steven J Clipman, Andrés G Lescano, Tabitha Bayangos and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Risk factors for vertical transmission of Chagas disease: A systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
    Pooled it
  2. Article
  3. Review
  4. Frontiers in microbiology · 2024
    Article
  5. Effects of EnterotoxigenicMicroorganisms · 2023
    Article
  6. Article
  7. Risk Factors for Maternal Chagas Disease and Vertical Transmission in a Bolivian Hospital.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Yagahira E Castro-SesquenDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Freddy TinajerosDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Caryn BernDepartment of Epidemiology and Biostatistics, University of California, San Francisco School of Medicine, San Francisco, California, USA.
Gerson Galdos-CardenasDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Edith S MalagaInfectious Diseases Research Laboratory, School of Science and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru.
Edward Valencia AyalaInfectious Diseases Research Laboratory, School of Science and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru.
Kathryn HjerrildInBios International, Inc, Seattle, Washington, USA.
Steven J ClipmanDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Andrés G LescanoEmerging Diseases and Climate Change Research Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru.
Tabitha BayangosDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Walter CastilloAsociación Benéfica PRISMA, Lima, Peru.
María Carmen MenduiñaPercy Boland Maternity Hospital, Santa Cruz, Bolivia.
Kawsar R TalaatDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Robert H GilmanDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Chagas Working Group in Bolivia and Peru
Johns Hopkins University · USUniversidad Peruana Cayetano Heredia · PEInBios International (United States) · USPrisma · PEUniversity of California, San Francisco · US

Funding

Peru Infectious Diseases Epidemiology Research Training ConsortiumD43TW007393 · FIC · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI Andres G Lescano · 2005 to 2026
$5.9M
Infectious Diseases Training program in Bolivia: South-South Training with PeruD43TW010074 · FIC · JOHNS HOPKINS UNIVERSITY · PI ROBERT H GILMAN, Jeffrey Tornheim · 2015 to 2026
$3.5M
Early Detection of Congenital Chagas DiseaseR01AI087776 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GILMAN, ROBERT H · 2010 to 2014
$2.9M
FIC NIH HHS D43 TW007393FIC NIH HHS D43 TW010074NIAID NIH HHS R01 AI087776
6 · The paper itself

Abstract

backgroundDiagnosis of congenital Chagas disease (CChD) in most endemic areas is based on low-sensitive microscopy at birth and 9-month immunoglobulin G (IgG), which has poor adherence. We aim to evaluate the accuracy of the Immunoglobulin M (IgM)-Shed Acute Phase Antigen (SAPA) test in the diagnosis of CChD at birth.

methodsTwo cohort studies (training and validation cohorts) were conducted in 3 hospitals in the department of Santa Cruz, Bolivia. Pregnant women were screened for Chagas disease, and all infants born to seropositive mothers were followed for up to 9 months to diagnose CChD. A composite reference standard was used to determine congenital infection and was based on the parallel use of microscopy, quantitative polymerase chain reaction (qPCR), and IgM-trypomastigote excreted-secreted antigen (TESA) blot at birth and/or 1 month, and/or the detection of anti-Trypanosoma cruzi IgG at 6 or 9 months. The diagnostic accuracy of the IgM-SAPA test was calculated at birth against the composite reference standard.

resultsAdherence to the 6- or 9-month follow-up ranged from 25.3% to 59.7%. Most cases of CChD (training and validation cohort: 76.5% and 83.7%, respectively) were detected during the first month of life using the combination of microscopy, qPCR, and/or IgM-TESA blot. Results from the validation cohort showed that when only 1 infant sample obtained at birth was evaluated, the qPCR and the IgM-SAPA test have similar accuracy (sensitivity: range, 79.1%-97.1% and 76.7%-94.3%, respectively, and specificity: 99.5% and 92.6%, respectively).

conclusionsThe IgM-SAPA test has the potential to be implemented as an early diagnostic tool in areas that currently rely only on microscopy.

Indexed as

Chagas DiseaseTrypanosoma cruziAntibodies, ProtozoanBoliviaEarly DiagnosisFemaleGoalsHumansImmunoglobulin MInfantInfant, NewbornInfectious Disease Transmission, VerticalPregnancyAntibodies, ProtozoanImmunoglobulin Mcongenital Chagas diseasediagnosticsIgM antibodiesshed acute-phase antigenTrypanosoma cruzi

Identifiers

PMID32667981
PMCPMC8282310
OpenAlexW3042745179

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.