ArticlePLoS genetics2020
A novel allele of ASY3 is associated with greater meiotic stability in autotetraploid Arabidopsis lyrata.
Article in PLoS genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Molecular mechanisms underlying seed enlargement mediated by seed coat development in autotetraploid castor bean.The Plant journal : for cell and molecular biology · 2026Article
- The meiotic achilles' heel: vulnerability and resilience under environmental stress.Protoplasma · 2026Review
- Patterns of Interploidy Admixture in Polyploid Complexes: Insights From Thymus Sect. Mastichina (Lamiaceae).Molecular ecology · 2026Article
- SCEP3 initiates synapsis and implements crossover interference in Arabidopsis.Nature plants · 2025Article
- Multiple Autopolyploid Arabidopsis lyrata Populations Stabilized by Long-Range Adaptive Introgression Across Eurasia.Molecular biology and evolution · 2025Article
- The plant early recombinosome: a high security complex to break DNA during meiosis.Plant reproduction · 2024Review
- Polyploids broadly generate novel haplotypes from trans-specific variation in Arabidopsis arenosa and Arabidopsis lyrata.PLoS genetics · 2024Article
- Complex Polyploids: Origins, Genomic Composition, and Role of Introgressed Alleles.Systematic biology · 2024Article
- Complex Evolutionary History With Extensive Ancestral Gene Flow in an African Primate Radiation.Molecular biology and evolution · 2023Article
- Genomics of plant speciation.Plant communications · 2023Review
- TurboID-based proteomic profiling of meiotic chromosome axes in Arabidopsis thaliana.Nature plants · 2023Article
- Ancestral self-compatibility facilitates the establishment of allopolyploids in Brassicaceae.Plant reproduction · 2023Review
- ASYNAPSIS 1 ensures crossover fidelity in polyploid wheat by promoting homologous recombination and suppressing non-homologous recombination.Frontiers in plant science · 2023Article
- Allele segregation analysis of FChromosoma · 2022Article
- Meiosis in allopolyploid Arabidopsis suecica.The Plant journal : for cell and molecular biology · 2022Article
- Interfered chromosome pairing at high temperature promotes meiotic instability in autotetraploid Arabidopsis.Plant physiology · 2022Article
- All Ways Lead to Rome-Meiotic Stabilization Can Take Many Routes in Nascent Polyploid Plants.Genes · 2022Review
- Genomic and Meiotic Changes Accompanying Polyploidization.Plants (Basel, Switzerland) · 2022Review
- Review
- A Duplicated Copy of the Meiotic GeneBiology · 2021Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
In this study we performed a genotype-phenotype association analysis of meiotic stability in 10 autotetraploid Arabidopsis lyrata and A. lyrata/A. arenosa hybrid populations collected from the Wachau region and East Austrian Forealps. The aim was to determine the effect of eight meiosis genes under extreme selection upon adaptation to whole genome duplication. Individual plants were genotyped by high-throughput sequencing of the eight meiosis genes (ASY1, ASY3, PDS5b, PRD3, REC8, SMC3, ZYP1a/b) implicated in synaptonemal complex formation and phenotyped by assessing meiotic metaphase I chromosome configurations. Our results reveal that meiotic stability varied greatly (20-100%) between individual tetraploid plants and associated with segregation of a novel ASYNAPSIS3 (ASY3) allele derived from A. lyrata. The ASY3 allele that associates with meiotic stability possesses a putative in-frame tandem duplication (TD) of a serine-rich region upstream of the coiled-coil domain that appears to have arisen at sites of DNA microhomology. The frequency of multivalents observed in plants homozygous for the ASY3 TD haplotype was significantly lower than in plants heterozygous for ASY3 TD/ND (non-duplicated) haplotypes. The chiasma distribution was significantly altered in the stable plants compared to the unstable plants with a shift from proximal and interstitial to predominantly distal locations. The number of HEI10 foci at pachytene that mark class I crossovers was significantly reduced in a plant homozygous for ASY3 TD compared to a plant heterozygous for ASY3 ND/TD. Fifty-eight alleles of the 8 meiosis genes were identified from the 10 populations analysed, demonstrating dynamic population variability at these loci. Widespread chimerism between alleles originating from A. lyrata/A. arenosa and diploid/tetraploids indicates that this group of rapidly evolving genes may provide precise adaptive control over meiotic recombination in the tetraploids, the very process that gave rise to them.
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