ArticleNano letters2020
Enhancing Surface Capture and Sensing of Proteins with Low-Power Optothermal Bubbles in a Biphasic Liquid.
Article in Nano letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Patterning of Multilayer Biointerfaces Driven by Microbubble Lithography Toward Optical Biochips.Advanced biology · 2026Article
- Multimodal Optothermal Manipulations along Various Surfaces.ACS nano · 2023Article
- Optothermal rotation of micro-/nano-objects.Chemical communications (Cambridge, England) · 2023Review
- Article
- Hybrid bilayer membranes as platforms for biomimicry and catalysis.Nature reviews. Chemistry · 2022Review
- Directed Assembly of Nanomaterials for Making Nanoscale Devices and Structures: Mechanisms and Applications.ACS nano · 2022Review
- Bubble-pen lithography: Fundamentals and applications: Nanoscience: Special Issue Dedicated to Professor Paul S. Weiss.Aggregate (Hoboken, N.J.) · 2022Article
- Investigating water/oil interfaces with opto-thermophoresis.Nature communications · 2022Article
- The role of temperature-induced effects generated by plasmonic nanostructures on particle delivery and manipulation: a review.Nanophotonics (Berlin, Germany) · 2022Review
- Heat-Mediated Optical Manipulation.Chemical reviews · 2022Review
- Plasmonic Nanotweezers and Nanosensors for Point-of-Care Applications.Advanced optical materials · 2021Article
- Article
- Liquid Optothermoelectrics: Fundamentals and Applications.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Sensitivity-Enhancing Strategies in Optical Biosensing.Small (Weinheim an der Bergstrasse, Germany) · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Molecular binding in surface-based biosensing is inherently governed by diffusional transport of molecules in solution to surface-immobilized counterparts. Optothermally generated surface microbubbles can quickly accumulate solutes at the bubble-liquid-substrate interface due to high-velocity fluid flows. Despite its potential as a concentrator, however, the incorporation of bubbles into protein-based sensing is limited by high temperatures. Here, we report a biphasic liquid system, capable of generating microbubbles at a low optical power/temperature by formulating PFP as a volatile, water-immiscible component in the aqueous host. We further exploited zwitterionic surface modification to prevent unwanted printing during bubble generation. In a single protein-protein interaction model, surface binding of dispersed proteins to capture proteins was enhanced by 1 order of magnitude within 1 min by bubbles, compared to that from static incubation for 30 min. Our proof-of-concept study exploiting fluid formulation and optothermal add-on paves an effective way toward improving the performances of sensors and spectroscopies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.