Evidence map›Paper›PMID 32667725›Full record

ArticleClinical and translational medicine2020

Whole-genome methylome analysis reveals age-related diabetes risk factors.

Luo Hai, Zongzhi Liu, Wei Chen, Jie Qiao, Yingli Sun

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luo HaiCentral Laboratory, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
Zongzhi LiuCentral Laboratory, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
Wei ChenDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University Third Hospital, Beijing, China.
Jie QiaoDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University Third Hospital, Beijing, China.
Yingli SunCentral Laboratory, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.ORCID https://orcid.org/0000-0002-1888-7661

Funding

100 Talents ProjectNational Basic Research Program of China 2012CB518302National Basic Research Program of China 2013CB911001National Natural Science Foundation of China 31100558National Natural Science Foundation of China 31471395National Natural Science Foundation of China 31540033National Natural Science Foundation of China 81702796National Natural Science Foundation of China 91019024Precision Medicine Research Program of the Chinese Academy of Sciences KJZD-EW-L14Strategic Priority Research Program of the Chinese Academy of Sciences XDA01040407
6 · The paper itself

Abstract

This study provides a new perspective on the relationship between age-related DNA methylation and insulin function. The hexokinase-1 (HK1)'s methylation level in the whole blood can be considered as a potential biomarker for the risk of diabetes in healthy individuals.

Indexed as

ageDNA methylationinsulin resistanceinsulin secretion

Identifiers

PMID32667725
PMCPMC7418808

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.