ArticleJournal of neurophysiology2020
Differences in estimated persistent inward currents between ankle flexors and extensors in humans.
Article in Journal of neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07226284 (The Effects of Vagus Nerve Stimulation on Intrinsic Lower Leg Spinal Motoneuron Excitability in Parkinson's Disease.), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Vagus Nerve Stimulation on Intrinsic Lower Leg Spinal Motoneuron Excitability in Parkinson's Disease.
Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Voluntary activation of the ankle dorsiflexors is overestimated using the interpolated twitch technique with electrical stimulation.European journal of applied physiology · 2026Article
- Isometric handgrip contraction increases tibialis anterior intrinsic motoneuron excitability in a dose-dependent manner.Experimental physiology · 2026Article
- Motor unit discharge properties of the vastii muscles and their modulation with contraction level depend on the knee-joint angle.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Article
- Centrally mediated responses to NMES are influenced by muscle group and stimulation parameters.Scientific reports · 2024Article
- Relationships among motor unit discharge parameters used to estimate synaptic inputs to motoneurons.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- Antagonist Activation Measurement in Triceps Surae Using High-Density and Bipolar Surface EMG in Chronic Hemiparesis.Sensors (Basel, Switzerland) · 2024Article
- Modified motor unit properties in residual muscle following transtibial amputation.Journal of neural engineering · 2024Article
- Estimates of persistent inward currents in lower limb motoneurons are larger in females than in males.Journal of neurophysiology · 2023Article
- Motor unit-based synergies in a non-compartmentalized muscle.Experimental brain research · 2023Article
- A geometric approach to quantifying the neuromodulatory effects of persistent inward currents on individual motor unit discharge patterns.Journal of neural engineering · 2023Article
- Molecular Identification of Pro-Excitogenic Receptor and Channel Phenotypes of the Deafferented Lumbar Motoneurons in the Early Phase after SCT in Rats.International journal of molecular sciences · 2022Article
- A computational approach for generating continuous estimates of motor unit discharge rates and visualizing population discharge characteristics.Journal of neural engineering · 2022Article
- The Cellular Basis for the Generation of Firing Patterns in Human Motor Units.Advances in neurobiology · 2022Article
- Firing rate trajectories of human occipitofrontalis motor units in response to triangular voluntary contraction intensity.Experimental brain research · 2021Article
- Intrinsic motoneuron excitability is reduced in soleus and tibialis anterior of older adults.GeroScience · 2021Article
- Estimates of persistent inward currents are reduced in upper limb motor units of older adults.The Journal of physiology · 2021Article
- Estimates of persistent inward currents in tibialis anterior motor units during standing ramped contraction tasks in humans.Journal of neurophysiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Persistent inward currents (PICs) are responsible for amplifying motoneuronal synaptic inputs and contribute to generating normal motoneuron activation. Delta-F (ΔF) is a well-established method that estimates PICs in humans indirectly from firing patterns of individual motor units. Traditionally, motor unit firing patterns are obtained by manually decomposing electromyography (EMG) signals recorded through intramuscular electrodes (iEMG). A previous iEMG study has shown that in humans the elbow extensors have higher ΔF than the elbow flexors. In this study, EMG signals were collected from the ankle extensors and flexors using high-density surface array electrodes during isometric sitting and standing at 10-30% maximum voluntary contraction. The signals were then decomposed into individual motor unit firings. We hypothesized that comparable to the upper limb, the lower limb extensor muscles (soleus) would have higher ΔF than the lower limb flexor muscles [tibialis anterior (TA)]. Contrary to our expectations, ΔF was higher in the TA than the soleus during sitting and standing despite the difference in cohort of participants and body positions. The TA also had significantly higher maximum discharge rate than the soleus while there was no difference in rate increase. When only the unit pairs with similar maximum discharge rates were compared, ∆F was still higher in the TA than the soleus. Future studies will focus on investigating the functional significance of the findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.