Evidence map›Paper›PMID 32667154›Full record

ArticleAnesthesiology2020

Perioperative Use of Gabapentinoids for the Management of Postoperative Acute Pain: A Systematic Review and Meta-analysis.

Michael Verret, François Lauzier, Ryan Zarychanski, Caroline Perron, Xavier Savard, Anne-Marie Pinard, Guillaume Leblanc, Marie-Joëlle Cossi, Xavier Neveu, Alexis F Turgeon and 1 more

Erratum issued 4 registry-linked trialsAbstract readComment
PubMed Publisher
In one paragraph

Article in Anesthesiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 4 registered trials, which are not on this map. Cited by 151 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04705480 phase4completednot on this mapstarted 2021, after this paper: background citation

Pregabalin vs. Gabapentin on Reducing Opioid Usage in Trauma Patients

TypeinterventionalSponsorCAMC Health SystemRan2021 to 2024Enrolled109ConditionsAnalgesics, Gabapentin, Injuries, NarcoticsArmsPregabalin 50mg, Gabapentin 300mg, Neither Pregabalin nor Gabapentin
NCT04741880 phase2 / phase3unknown statusnot on this mapstarted 2021, after this paper: background citation

Intravenous Lidocaine and Time to Regression of the Sensory Block After Spinal Anesthesia With Isobaric Bupivacaine in Patients Undergoing Surgery to Treat Skin and Soft Tissue Tumors of the Lower Limbs

TypeinterventionalSponsorInstituto Nacional de Cancer, BrazilRan2021 to 2023Enrolled66ConditionsAnesthesia, CancerArmsLidocaine IV, Saline
NCT05658887 phase4completednot on this mapstarted 2023, after this paper: background citation

A Double-Blind Randomized Placebo-Controlled Clinical Trial of Preoperative Gabapentin Prior to Vaginal Apical Suspension Prolapse Procedures

TypeinterventionalSponsorJoseph KowalskiRan2023 to 2024Enrolled110ConditionsPelvic Organ Prolapse, Perioperative/Postoperative ComplicationsArmsGabapentin, Gabapentin Placebo
NCT06946290 narecruitingnot on this mapstarted 2026, after this paper: background citation

Intertransverse Process Block to Improve Quality of Recovery and Pain Management in Adult Cardiac Surgical Patients: a Prospective Double-Blinded Randomized Controlled Trial

TypeinterventionalSponsorChinese University of Hong KongRan2026 to 2028Enrolled96ConditionsChronic Postsurgical PainArmsIntertransverse process block, Sham block
3 · Its place in the literature

Who cites it

151 citing papers in PubMed, 15 syntheses or guidelines pooled it.

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91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Michael VerretFrom the Population Health and Optimal Health Practices Research Unit, Trauma-Emergency-Critical Care Medicine, CHU de Québec - Université Laval Research Center, Québec City, Québec, Canada (M.V., F.L., C.P., X.S., A.-M.P., G.L., M.-J.C., X.N., A.F.T.) the Division of Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine (M.V., F.L., A.-M.P., G.L., A.F.T.) the Department of Medicine (F.L.) Faculty of Medicine, and the Interdisciplinary Research Centre for Rehabilitation and Social Integration (A.-M.P.), Université Laval, Québec City, Québec, Canada the Department of Internal Medicine, Section of Critical Care, University of Manitoba, Winnipeg, Manitoba, Canada (R.Z.) the Department of Haematology and Medical Oncology, Cancer Care Manitoba, Winnipeg, Manitoba, Canada (R.Z.).
François Lauzier
Ryan Zarychanski
Caroline Perron
Xavier Savard
Anne-Marie Pinard
Guillaume Leblanc
Marie-Joëlle Cossi
Xavier Neveu
Alexis F Turgeon
Canadian Perioperative Anesthesia Clinical Trials (PACT) Group

Funding

CIHR 354039
6 · The paper itself

Abstract

backgroundWidely used for acute pain management, the clinical benefit from perioperative use of gabapentinoids is uncertain. The aim of this systematic review was to assess the analgesic effect and adverse events with the perioperative use of gabapentinoids in adult patients.

methodsRandomized controlled trials studying the use of gabapentinoids in adult patients undergoing surgery were included. The primary outcome was the intensity of postoperative acute pain. Secondary outcomes included the intensity of postoperative subacute pain, incidence of postoperative chronic pain, cumulative opioid use, persistent opioid use, lengths of stay, and adverse events. The clinical significance of the summary estimates was assessed based on established thresholds for minimally important differences.

resultsIn total, 281 trials (N = 24,682 participants) were included in this meta-analysis. Compared with controls, gabapentinoids were associated with a lower postoperative pain intensity (100-point scale) at 6 h (mean difference, -10; 95% CI, -12 to -9), 12 h (mean difference, -9; 95% CI, -10 to -7), 24 h (mean difference, -7; 95% CI, -8 to -6), and 48 h (mean difference, -3; 95% CI, -5 to -1). This effect was not clinically significant ranging below the minimally important difference (10 points out of 100) for each time point. These results were consistent regardless of the type of drug (gabapentin or pregabalin). No effect was observed on pain intensity at 72 h, subacute and chronic pain. The use of gabapentinoids was associated with a lower risk of postoperative nausea and vomiting but with more dizziness and visual disturbance.

conclusionsNo clinically significant analgesic effect for the perioperative use of gabapentinoids was observed. There was also no effect on the prevention of postoperative chronic pain and a greater risk of adverse events. These results do not support the routine use of pregabalin or gabapentin for the management of postoperative pain in adult patients.

Indexed as

Acute PainAdultAnalgesicsGabapentinHumansPostoperative PainPregabalinAnalgesicsGabapentinPregabalin

Identifiers

PMID32667154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.