Evidence map›Paper›PMID 32667138›Full record

ArticleJournal of cellular and molecular medicine2020

Exogenous neuritin treatment improves survivability and functions of Schwann cells with improved outgrowth of neurons in rat diabetic neuropathy.

Chunhong Xi, Yingduan Zhang, Mei Yan, Qing Lv, Huan Lu, Jun Zhou, Yucheng Wang, Jianbo Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. [Research advances on the role of Schwann cells in diabetic peripheral neuropathy].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Chunhong XiEndocrinology and Metabolism Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yingduan ZhangEndocrinology and Metabolism Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Mei YanEndocrinology and Metabolism Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Qing LvEndocrinology and Metabolism Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Huan LuEndocrinology and Metabolism Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jun ZhouEndocrinology and Metabolism Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yucheng WangEndocrinology and Metabolism Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jianbo LiEndocrinology and Metabolism Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID 0000-0002-1096-0836
Jiangsu Province Hospital · CNChinese Nutrition Society · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogenesis and treatment for diabetic neuropathy are still complex. A deficit of neurotrophic factors affecting Schwann cells is a very important cause of diabetic neuropathy. Neuritin is a newly discovered potential neurotrophic factor. In this study, we explored the effect of exogenous neuritin on survivability and functions of diabetic Schwann cells of rats with experimental diabetic neuropathy. Diabetic neuropathy was induced in rats. 12-week diabetic rats contrasted with non-diabetic normal rats had decreased levels of serum neuritin and slowed nerve conduction velocities (NCVs). Schwann cells isolated from these diabetic rats and cultured in high glucose showed reduced cell neuritin mRNA and protein and supernatant neuritin protein, increased apoptosis rates, increased caspase-3 activities and progressively reduced viability. In contrast, exogenous neuritin treatment reduced apoptosis and improved viability, with elevated Bcl-2 levels (not Bax) and decreased caspase-3 activities. Co-cultured with diabetic Schwann cells pre-treated with exogenous neuritin in high glucose media, and diabetic DRG neurons showed lessened decreased neurite outgrowth and supernatant NGF concentration occurring in co-culture of diabetic cells. Exogenous neuritin treatment ameliorated survivability and functions of diabetic Schwann cells of rats with diabetic neuropathy. Our study may provide a new mechanism and potential treatment for diabetic neuropathy.

Indexed as

AnimalsApoptosisCells, CulturedDiabetes Mellitus, ExperimentalDiabetic NeuropathiesDisease Models, AnimalGlucoseGPI-Linked ProteinsMaleNerve Growth FactorsNeuronsNeuropeptidesProto-Oncogene Proteins c-bcl-2RatsRats, Sprague-DawleyRNA, MessengerGlucoseGPI-Linked ProteinsNerve Growth FactorsNeuropeptidesNrn1 protein, ratProto-Oncogene Proteins c-bcl-2RNA, Messengerdiabetic neuropathyneuritinneuron outgrowthratsSchwann cell survival

Identifiers

PMID32667138
PMCPMC7520300
OpenAlexW3043624551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.