ArticleEMBO molecular medicine2020
Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity.
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Article in EMBO molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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76citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
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76 citing papers in PubMed, 114 citations in OpenAlex.
- Targeting common denominators of DNA damage tolerance mechanisms as therapeutic strategy to cope with dynamic phenotypic changes in triple-negative breast cancer cells.Cell death discovery · 2026Article
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- Distinct 2-phenylimidazo[1,2-iScience · 2026Article
- Preclinical models of breast cancer metastasis: strengths, limitations, and clinical relevance.NPJ breast cancer · 2026Review
- Clinical applications and future perspectives of circulating tumor cells in solid tumors.Discover oncology · 2026Review
- Novel Cell Cycle Inhibitors Decrease Primary and Metastatic Breast Cancer Growth In Vivo.Cancers · 2026Article
- Reconstructing the metastatic journey: functional circulating tumor cells and disseminated tumor cells based models for translational oncology.Journal of experimental & clinical cancer research : CR · 2026Review
- Advancements in Circulating Tumor Cell Expansion Ex Vivo: A Matured Technology?Methods in molecular biology (Clifton, N.J.) · 2026Article
- The Impact of Combretastatin A-4 on Cancer Cells and Circulating Tumor Cells (CTCs): A Multi-Assay Approach.Oncology research · 2026Article
- Circulating tumor cells in breast cancer bone metastasis: mechanisms, clinical relevance, and future directions.Cell death discovery · 2025Review
- Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients.Molecular oncology · 2025Article
- Deciphering Breast Tumor Heterogeneity Through Patient-Derived Organoids and Circulating Tumor Cells.Journal of personalized medicine · 2025Review
- Rapid Recovery and Short-Term Culture of Gastric Circulating Tumor Cells Using Microcavity Array.Engineering in life sciences · 2025Article
- Lessons (to be) learned from liquid biopsies: assessment of circulating cells and cell-free DNA in cancer and pregnancy-acquired microchimerism.Seminars in immunopathology · 2025Review
- Discovery of a sushi domain-containing protein 2-positive phenotype in circulating tumor cells of metastatic breast cancer patients.Scientific reports · 2025Article
- Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1-HER3 signaling.Nature cancer · 2025Article
- Clinical significance and heterogeneity of circulating tumor cells and clusters in breast cancer subtypes.PeerJ · 2025Review
- Multi-stage mechanisms of tumor metastasis and therapeutic strategies.Signal transduction and targeted therapy · 2024Review
- Single-cell and spatial omics unravel the spatiotemporal biology of tumour border invasion and haematogenous metastasis.Clinical and translational medicine · 2024Review
- Analysis of the Plasticity of Circulating Tumor Cells Reveals Differentially Regulated Kinases During the Suspension-to-Adherent Transition.Cancer medicine · 2024Article
16 more citing papers are in PubMed but not listed here.
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Authors and funding
31 authors at 10 institutions in 7 countries.
Claudia Koch *Department of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Andra Kuske *Department of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Simon A JoosseDepartment of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-4296-5615
Gökhan YigitInstitute of Human Genetics, University Medical Center Göttingen, Göttingen, Germany.
George SflomosISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID 0000-0003-2972-0549
Sonja ThalerEuropean Centre for Angioscience (ECAS), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Daniel J SmitInstitute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-3190-9511
Stefan WernerDepartment of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Kerstin BorgmannRadiobiology& Experimental Radiooncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Sebastian GärtnerDepartment of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Parinaz Mossahebi MohammadiDepartment of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Laura BattistaISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Laure CayrefourcqLaboratory of Rare Human Circulating Cells (LCCRH), University Medical Centre, Montpellier, France.
Janine AltmüllerCologne Center for Genomics, University of Cologne, Cologne, Germany.
Gabriela Salinas-RiesterNGS Integrative Genomics Core Unit, Institute of Human Genetics, University Medical Center Göttingen, Göttingen, Germany.
Kaamini RaithathaNGS Integrative Genomics Core Unit, Institute of Human Genetics, University Medical Center Göttingen, Göttingen, Germany.
Arne ZibatInstitute of Human Genetics, University Medical Center Göttingen, Göttingen, Germany.
Yvonne GoyRadiobiology& Experimental Radiooncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Leonie OttDepartment of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Kai BartkowiakDepartment of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Tuan Zea TanCancer Science Institute of Singapore, National University of Singapore, Singapore City, Singapore.ORCID 0000-0001-6624-1593
Qing ZhouInstitute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Graz, Austria.ORCID 0000-0001-7737-9643
Michael R SpeicherInstitute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Graz, Austria.ORCID 0000-0003-0105-955X
Volkmar MüllerDepartment of Gynecology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Tobias M GorgesDepartment of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Manfred JückerInstitute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jean-Paul ThieryINSERM Unit 1186, Comprehensive Cancer Center, Institut Gustave Roussy, Villejuif, France.ORCID 0000-0003-0478-5020
Cathrin Brisken *ISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Sabine Riethdorf *Department of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0003-0028-5643
Catherine Alix-Panabières *Laboratory of Rare Human Circulating Cells (LCCRH), University Medical Centre, Montpellier, France.ORCID 0000-0002-6401-2903
Klaus PantelDepartment of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0001-5736-2772
Universität Hamburg · DEUniversitätsmedizin Göttingen · DEMedical University of Graz · ATSwiss Cancer Center Léman · CHUniversité de Montpellier · FRHeidelberg University · DEInserm · FRInstitute of Cancer Research · GBNational University of Singapore · SGUniversity of Cologne · DE
Funding
Deutsche Forschungsgemeinschaft SPP2084 μBoneDeutsche Forschungsgemeinschaft TH 1523/3-1Deutsche Krebshilfe (German Cancer Aid) 70112504European Research Council Advanced Investigator Grant 834974Fondation BiltemaInnovative Medicines Initiative (IMI) 115749-CANCER-IDISREC Fondation Recherche CancerSwiss Cancer League KFS-3701-08-2015
Abstract
Functional studies giving insight into the biology of circulating tumor cells (CTCs) remain scarce due to the low frequency of CTCs and lack of appropriate models. Here, we describe the characterization of a novel CTC-derived breast cancer cell line, designated CTC-ITB-01, established from a patient with metastatic estrogen receptor-positive (ER
Indexed as
Breast NeoplasmsNeoplastic Cells, CirculatingAnimalsBiomarkers, TumorCarcinogenesisDNA Copy Number VariationsFemaleHumansMiceNeoplasm MetastasisBiomarkers, Tumorbreast cancercirculating tumor cellsfunctional studiesliquid biopsymetastasis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.