Evidence map›Paper›PMID 32667048›Full record

ArticleThe Journal of physiology2020

Extracellular GABA waves regulate coincidence detection in excitatory circuits.

Sergiy Sylantyev, Leonid P Savtchenko, Nathanael O'Neill, Dmitri A Rusakov

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sergiy SylantyevRowett Institute, University of Aberdeen, Ashgrove Rd. West, Aberdeen, AB25 2ZD, UK.ORCID 0000-0002-1358-0601
Leonid P SavtchenkoUCL Queen Square Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
Nathanael O'NeillCentre for Clinical Brain Sciences, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.
Dmitri A RusakovUCL Queen Square Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.ORCID 0000-0001-9539-9947
Queen Mary University of London · GBMRC Centre for Regenerative Medicine · GB

Funding

European Research Council 323113Wellcome Trust 212251/Z/18/ZWellcome Trust 212251_Z_18_Z
6 · The paper itself

Abstract

key pointsRapid changes in neuronal network activity trigger widespread waves of extracellular GABA in hippocampal neuropil. Elevations of extracellular GABA narrow the coincidence detection window for excitatory inputs to CA1 pyramidal cells. GABA transporters control the effect of extracellular GABA on coincidence detection. Small changes in the kinetics of dendritic excitatory currents amplify when reaching the soma. ABSTRACT: Coincidence detection of excitatory inputs by principal neurons underpins the rules of signal integration and Hebbian plasticity in the brain. In the hippocampal circuitry, detection fidelity is thought to depend on the GABAergic synaptic input through a feedforward inhibitory circuit also involving the hyperpolarisation-activated I

Indexed as

Pyramidal CellsReceptors, GABA-AAnimalsgamma-Aminobutyric AcidHippocampusNeuronsRatsgamma-Aminobutyric AcidReceptors, GABA-Aextracellular GABAHebbian learninginput coincidence detection

Identifiers

PMID32667048
PMCPMC8432164
OpenAlexW3043628879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.