Evidence map›Paper›PMID 32666702›Full record

ArticleMolecular genetics & genomic medicine2020

Association of genetic variants at CETP, AGER, and CYP4F2 locus with the risk of atrophic age-related macular degeneration.

Rasa Liutkeviciene, Alvita Vilkeviciute, Loresa Kriauciuniene, Mantas Banevicius, Brigita Budiene, Daiva Stanislovaitiene, Reda Zemaitiene, Vytenis P Deltuva

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Article in Molecular genetics & genomic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rasa LiutkevicieneNeuroscience Institute, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania.ORCID 0000-0001-5395-923X
Alvita VilkeviciuteNeuroscience Institute, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania.
Loresa KriauciunieneNeuroscience Institute, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania.
Mantas BaneviciusDepartment of Ophthalmology, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania.
Brigita BudieneDepartment of Ophthalmology, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania.
Daiva StanislovaitieneDepartment of Ophthalmology, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania.
Reda ZemaitieneDepartment of Ophthalmology, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania.
Vytenis P DeltuvaNeuroscience Institute, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania.
Lithuanian University of Health Sciences · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAge-related macular degeneration (AMD) is the leading cause of blindness in the elderly individuals. The etiology of AMD includes environmental and genetic factors.

methodsWe aimed to determine the association between CETP (rs5882; rs708272; rs3764261; rs1800775; rs2303790), AGER (rs1800624; rs1800625), and CYP4F2 (rs1558139) gene polymorphisms and development of atrophic AMD. About 52 patients with atrophic AMD and 800 healthy control subjects were evaluated. The genotyping of single-nucleotide polymorphisms in CETP, AGER, and CYP4F2 was carried out using the real-time-PCR method.

resultsGenetic risk models in the analysis of CETP rs5882 revealed statistically significant variables with increased risk of atrophic AMD in the codominant (p < .001), dominant (p < .001), recessive (p < .001), and additive (p < .001) models with the highest 25.4-fold increased risk of atrophic AMD in the codominant model (p < .001). The AGER rs1800625 was associated with a highly increased risk of atrophic AMD in the codominant (p < .001), recessive (p < .001), and additive (p < .001) genetic models.

conclusionWe identified two polymorphisms with a higher risk of atrophic AMD (CETP rs5882 and AGER rs1800625).

Indexed as

Polymorphism, Single NucleotideAgedAged, 80 and overCholesterol Ester Transfer ProteinsCytochrome P450 Family 4FemaleHumansMacular DegenerationMaleReceptor for Advanced Glycation End ProductsAGER protein, humanCETP protein, humanCholesterol Ester Transfer ProteinsCYP4F2 protein, humanCytochrome P450 Family 4Receptor for Advanced Glycation End ProductsAGERage-related macular degenerationCETPCYP4F2gene polymorphism

Identifiers

PMID32666702
PMCPMC7507364
OpenAlexW3042914163

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.