ArticleCNS neuroscience & therapeutics2020
Hypercapnia promotes microglial pyroptosis via inhibiting mitophagy in hypoxemic adult rats.
Article in CNS neuroscience & therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Molecular and Cellular Signaling Pathways of the Effects of Hypoxia and Hypercapnia on the Mechanisms of Neuroinflammation.International journal of molecular sciences · 2026Review
- Exploring the Association Between Early PaCOTranslational stroke research · 2025Article
- NLRP3 inflammasome inhibits mitophagy during the progression of temporal lobe epilepsy.Scientific reports · 2025Article
- The Role of N6-Methyladenosine in Mitochondrial Dysfunction and Pathology.International journal of molecular sciences · 2025Review
- Microglia programmed cell death in neurodegenerative diseases and CNS injury.Apoptosis : an international journal on programmed cell death · 2025Review
- Crosstalk Between Cell Death and the cGAS-STING Pathway in Sepsis-Associated Acute Lung Injury.Journal of inflammation research · 2025Review
- Macrophage pyroptosis and its crucial role in ALI/ARDS.Frontiers in immunology · 2025Review
- Progress on the Effects of Permissive Hypercapnia on the CNS During the Intraoperative Period: A Narrative Review.Cureus · 2024Review
- Hyperglycemia induces microglial pyroptosis by increasing oxygen extraction rate: Implication in neurological impairment during ischemic stroke.Molecular medicine reports · 2024Article
- The Role of Pyroptosis and Autophagy in the Nervous System.Molecular neurobiology · 2024Review
- Mitophagy-associated programmed neuronal death and neuroinflammation.Frontiers in immunology · 2024Review
- Mitochondria-associated programmed cell death as a therapeutic target for age-related disease.Experimental & molecular medicine · 2023Review
- Dehydroepiandrosterone alleviates hypoxia-induced learning and memory dysfunction by maintaining synaptic homeostasis.CNS neuroscience & therapeutics · 2022Article
- Acute high-altitude hypoxia exposure causes neurological deficits via formaldehyde accumulation.CNS neuroscience & therapeutics · 2022Article
- Fisetin ameliorates cognitive impairment by activating mitophagy and suppressing neuroinflammation in rats with sepsis-associated encephalopathy.CNS neuroscience & therapeutics · 2022Article
- Mitophagy in Traumatic Brain Injury: A New Target for Therapeutic Intervention.Oxidative medicine and cellular longevity · 2022Review
- PAF Receptor Inhibition Attenuates Neuronal Pyroptosis in Cerebral Ischemia/Reperfusion Injury.Molecular neurobiology · 2021Article
- Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Attenuate Oxygen-Glucose Deprivation/Reperfusion-Induced Microglial Pyroptosis by Promoting FOXO3a-Dependent Mitophagy.Oxidative medicine and cellular longevity · 2021Article
- Hypercapnia promotes microglial pyroptosis via inhibiting mitophagy in hypoxemic adult rats.CNS neuroscience & therapeutics · 2020Article
- The Role of Mitochondria in Pyroptosis.Frontiers in cell and developmental biology · 2020Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypoxemia is a typical symptom of acute respiratory distress syndrome. To avoid pulmonary morbidity, low tidal volume ventilation is often applied. The ventilation strategy will certainly cause hypercapnia. This study aimed to explore whether hypercapnia would promote microglial pyroptosis via inhibiting mitophagy in adult rats with hypoxemia.
methodsThe cerebral oxygen extraction ratio (CERO
resultsHypercapnia decreased the PbtO
conclusionsThese results suggest that hypercapnia-induced mitophagy inhibition may promote pyroptosis and enhance IL-1β and IL-18 release in hypoxia-activated microglia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.