Evidence map›Paper›PMID 32666663›Full record

ArticleAdvanced healthcare materials2020

Microporous Biodegradable Films Promote Therapeutic Angiogenesis.

Eseelle K Hendow, Mehran Moazen, Francesco Iacoviello, Laurent Bozec, Caroline Pellet-Many, Richard M Day

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Fabrication of New Hybrid Scaffolds forFrontiers in cardiovascular medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Eseelle K HendowCentre for Precision Healthcare, UCL Division of Medicine, University College London, Gower Street, London, WC1E 6BT, UK.
Mehran MoazenUCL Mechanical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.
Francesco IacovielloElectrochemical Innovation Lab, UCL Department of Chemical Engineering, University College London, Roberts Building, London, WC1E 7JE, UK.
Laurent BozecFaculty of Dentistry, University of Toronto, 124 Edwards Street, Toronto, Ontario, M5G 1G6, Canada.
Caroline Pellet-ManyDepartment of Comparative Biomedical Sciences, Royal Veterinary College, 4 Royal College Street, London, NW1 0TU, UK.
Richard M DayCentre for Precision Healthcare, UCL Division of Medicine, University College London, Gower Street, London, WC1E 6BT, UK.ORCID 0000-0002-3124-2294
University College London · GBRoyal Veterinary College · GBThe London College · GBUniversity of Toronto · CA

Funding

British Heart Foundation FS/14/67/31294British Heart Foundation PG/16/56/32246British Heart Foundation PG/16/84/32464Medical Research Council MC_PC_16063
6 · The paper itself

Abstract

Peripheral arterial disease and critical limb ischemia are common symptoms of cardiovascular disease. Vascular surgery is used to create a bypass around occluded blood vessels to improve blood flow to ischemic muscle, thus avoiding the need for amputation. Attempts to vascularize tissues by therapeutic angiogenesis using delivery of exogenous angiogenic agents are underwhelming. A material-based approach that provides an endogenous stimulus capable of promoting angiogenesis and increased tissue perfusion would provide a paradigm shift in treatment options available. It is reported here that microporous biodegradable films produced using thermally induced phase separation provide a localized biophysical stimulus of proangiogenic genes in vivo that is associated with increased blood vessel density and restoration of blood flow to ischemic tissue. These findings show, for the first time, that acellular, nonfunctionalized biodegradable biomaterials can provide an innovative, material-based approach for therapeutic angiogenesis to enhance tissue reperfusion in vivo.

Indexed as

IschemiaNeovascularization, PhysiologicAnimalsBiocompatible MaterialsDisease Models, AnimalHindlimbNeovascularization, PathologicBiocompatible Materialspoly(d,l-lactide-co-glycolide)therapeutic angiogenesisthermally induced phase separation

Identifiers

PMID32666663
PMCPMC8427471
OpenAlexW3042969200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.