Evidence map›Paper›PMID 32666651›Full record

ArticleAddiction biology2021

Incubation of alcohol craving as it naturally occurs in a developmentally diverse sample of dependent and nondependent drinkers.

Hayley Treloar Padovano, Robert Miranda

Abstract read
In one paragraph

Article in Addiction biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hayley Treloar PadovanoDepartment of Psychiatry and Human Behavior, Department of Behavioral and Social Sciences, Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, USA.ORCID 0000-0001-5347-4291
Robert MirandaDepartment of Psychiatry and Human Behavior, Department of Behavioral and Social Sciences, Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, USA.ORCID 0000-0001-6418-6148

Funding

NALTREXONE, CRAVING AND DRINKING: ECOLOGICAL ASSESSMENTR01AA007850 · NIAAA · BROWN UNIVERSITY · PI MIRANDA, ROBERT · 1988 to 2015
$8.4M
Mentored Patient-Oriented Research on Adolescent Alcohol Misuse and TreatmentK24AA026326 · NIAAA · BROWN UNIVERSITY · PI ROBERT MIRANDA · 2018 to 2026
$1.7M
Novel Approaches to Understanding How Alcohol Pathology Develops in AdolescentsK23AA024808 · NIAAA · BROWN UNIVERSITY · PI TRELOAR PADOVANO, HAYLEY · 2017 to 2021
$973k
Mechanisms of Naltrexone Action on Drinking in AdolescentsR21AA017273 · NIAAA · BROWN UNIVERSITY · PI MIRANDA, ROBERT · 2008 to 2009
$423k
NIAAA NIH HHS K23 AA024808NIAAA NIH HHS K24 AA026326NIAAA NIH HHS R01 AA007850NIAAA NIH HHS R21 AA017273
6 · The paper itself

Abstract

Longer periods of abstinence are shown to enhance response to alcohol cues among alcohol-dependent animals and humans, a phenomenon described as "incubation of craving." The present work examined the effects of days since last drink on general craving and alcohol-cued craving as it occurs in daily life and explored whether effects were influenced by age and dependence. Three samples were combined to include 266 drinkers ranging in age from 14 to 67 years recruited from the community; about half (59.4%) met criteria for alcohol dependence. Drinkers used handheld electronic devices to rate their subjective alcohol craving (assessed as "urge to drink") and situational context (e.g., presence of visible alcohol cues) at nondrinking times in daily life, with days since last alcohol use culled from timeline follow-back interviews and real-world reports. Drinkers at the lower end of the age range in this sample reported greater intensification of craving with more days of continuous abstinence than drinkers at the upper end of the age range. Age was not related to incubation of cue-elicited craving, in specific, however. For drinkers with dependence, craving when in the presence of visible alcohol cues intensified with more days of continuous abstinence, suggesting craving incubation. This study builds from important foundational work to demonstrate that incubation of cue-elicited craving occurs in dependent drinkers and applies regardless of age. Inasmuch as craving is a motivational drive that maintains alcohol use, understanding factors that influence craving in daily life holds promise for improving clinical care.

Indexed as

CuesAdolescentAdultAgedAlcohol DrinkingAlcoholismCravingFemaleHumansMaleMiddle AgedYoung Adultabstinencealcohol dependencecue reactivityecological momentary assessmentincubation of craving

Identifiers

PMID32666651
PMCPMC7855265

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.