Evidence map›Paper›PMID 32666413›Full record

ArticleObesity surgery2020

Acute and Chronic Impact of Biliopancreatic Diversion with Duodenal Switch Surgery on Plasma Lipoprotein(a) Levels in Patients with Severe Obesity.

Audrey-Anne Després, Marie-Eve Piché, Audrey Auclair, Laurent Biertho, Simon Marceau, Frédéric-Simon Hould, Simon Biron, Stéfane Lebel, Odette Lescelleur, François Julien and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Obesity surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Audrey-Anne DesprésCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Y-3601, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Québec, QC, G1V 4G5, Canada.ORCID 0000-0002-0285-3512
Marie-Eve PichéCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Y-3601, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Québec, QC, G1V 4G5, Canada.
Audrey AuclairCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Y-3601, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Québec, QC, G1V 4G5, Canada.
Laurent BierthoCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Y-3601, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Québec, QC, G1V 4G5, Canada.
Simon MarceauCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Y-3601, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Québec, QC, G1V 4G5, Canada.
Frédéric-Simon HouldCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Y-3601, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Québec, QC, G1V 4G5, Canada.
Simon BironCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Y-3601, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Québec, QC, G1V 4G5, Canada.
Stéfane LebelCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Y-3601, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Québec, QC, G1V 4G5, Canada.
Odette LescelleurCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Y-3601, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Québec, QC, G1V 4G5, Canada.
François JulienCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Y-3601, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Québec, QC, G1V 4G5, Canada.
Julie MartinCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Y-3601, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Québec, QC, G1V 4G5, Canada.
André TchernofCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Y-3601, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Québec, QC, G1V 4G5, Canada.
Patrick MathieuCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Y-3601, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Québec, QC, G1V 4G5, Canada.
Paul PoirierCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Y-3601, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Québec, QC, G1V 4G5, Canada.
Benoit J ArsenaultCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Y-3601, Pavillon Marguerite D'Youville, 2725 chemin Ste-Foy, Québec, QC, G1V 4G5, Canada. benoit.arsenault@criucpq.ulaval.ca.
Institut universitaire de cardiologie et de pneumologie de Québec · CA

Funding

CIHR
6 · The paper itself

Abstract

backgroundElevated lipoprotein(a) (Lp(a)) level is an independent risk factor for cardiovascular diseases. Lifestyle intervention studies targeting weight loss revealed little to no significant changes in Lp(a) levels. The impact of interventions that induce substantial weight loss, such as bariatric surgery, on Lp(a) levels is currently unclear.

objectiveTo determine the acute and long-term impact of bariatric surgery on Lp(a) levels in patients with severe obesity.

methodsSixty-nine patients with severe obesity underwent biliopancreatic diversion with duodenal switch (BPD-DS) surgery. The lipid profile was evaluated and Lp(a) levels were measured before surgery and at 6 and 12 months after BPD-DS surgery.

resultsMedian Lp(a) levels at baseline were 11.1 (4.1-41.6) nmol/L. Six months and 12 months after the BDP-DS surgery, we observed an improvement of lipid profile. At 6 months, we observed a 13% decrease in Lp(a) levels (9.7 (2.9-25.6) nmol/L, p < 0.0001) but this decrease was not sustained at 12 months (11.1 (3.9-32.8) nmol/L, p = 0.8). When the patients were separated into tertiles according to Lp(a) levels at baseline, we observed that the Lp(a) reduction at 12 months after BPD-DS surgery remained significant but modest in patients of the top Lp(a) tertile.

conclusionOur results suggest that BPD-DS surgery modestly reduces Lp(a) levels in the short term (6 months) in patients with severe obesity but this improvement is sustained over time only in patients with higher Lp(a) levels.

Indexed as

Bariatric SurgeryBiliopancreatic DiversionObesity, MorbidDuodenumHumansLipoprotein(a)PlasmaLipoprotein(a)Bariatric surgeryLipoprotein(a)Low-density lipoprotein cholesterolSevere obesityStatins

Identifiers

PMID32666413
OpenAlexW3042841923

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.