ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2020
Depression, temporomandibular disorders, and genetic polymorphisms in IL6 impact on oral health-related quality of life in patients requiring orthognathic surgery.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 24 citations in OpenAlex.
- Insomnia with objective short sleep duration in women with temporomandibular joint disorder: quantitative sensory testing, inflammation and clinical pain profiles.Sleep medicine · 2022Trial
- Somatic and psychiatric aspects of complications outside the surgical area in orthognathic surgery: A retrospective study of 429 patients.Medicina oral, patologia oral y cirugia bucal · 2026Article
- Impact of Cytokine Genes on TMD and QoL in Construction Workers.Brazilian dental journal · 2026Article
- Is there an association between superoxide dismutase gene polymorphisms, antioxidants in oxidative stress pathway, and oral health-related quality of life after root canal treatment?Acta odontologica Scandinavica · 2025Article
- Temporomandibular joint disorders, happiness, and COMT, HTR2A and FKBP5 polymorphisms in adolescents: a cross-sectional study.Brazilian oral research · 2025Article
- Ketoprofen Associated with Hyaluronic Acid Hydrogel for Temporomandibular Disorder Treatment: An In Vitro Study.Gels (Basel, Switzerland) · 2024Article
- Meta-analysis with systematic review to synthesize associations between oral health related quality of life and anxiety and depression.BDJ open · 2024Review
- Influence of genetic polymorphisms on oral health-related quality of life after root canal treatment.Brazilian dental journal · 2024Article
- Do SOD2 and SOD3 gene polymorphisms impact the oral health-related quality of life in Para athletes?Brazilian oral research · 2024Article
- Temporomandibular Disorders at the Preoperative Time of Orthognathic Surgery.Diagnostics (Basel, Switzerland) · 2023Article
- Focus Groups to Inform the Development of a Patient-Reported Outcome Measure (PROM) for Temporomandibular Joint Disorders (TMDs).The patient · 2023Article
- Genetic polymorphisms are involved in oral health-related quality of life in skeletal class III patients submitted to orthognathic surgery.Clinical oral investigations · 2023Article
- Observational
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
purposeTo assess oral health-related quality of life (OHRQoL) in patients requiring orthognathic surgery, and evaluate if depression, temporomandibular disorders (TMD), and genetic polymorphisms in interleukin-6 (IL6) influence their OHRQoL.
methodsA total of 132 individuals included in three different groups. Two groups were composed by patients with dentofacial deformity (DFD) Class II (n = 44) or Class III (n = 44) malocclusions, requiring orthognathic surgery. The control group (n = 44) included individuals without DFD. Patients from all groups were evaluated in preoperative appointments to assessOHRQoL, TMD, and genetic polymorphisms in IL6. OHRQoL was assessed using the 14-item Oral Health Impact Profile (OHIP-14). TMD and depression were assessed using Research Diagnostic Criteria for Temporomandibular Disorders protocol. The genetic polymorphisms rs1800795 and rs1800796 in IL6 were assessed through genomic DNA using real-time polymerase chain reaction.
resultsOHIP-14 scores were increased in patients with depression, myofascial pain, and inflammatory temporomandibular joint alterations in the right side, regardless of sex and DFD group. Individual homozygous CC in rs1800795 had increased values in domains "social disability" and "handicap" of the OHIP-14 compared with those who were homozygous GG. Individual heterozygous CG in the rs1800796 demonstrated increased values in domain "psychological discomfort" compared with those homozygous for CC and GG.
conclusionIn individuals requiring orthognathic surgery, depression, TMD, and genetic polymorphisms in IL6 contribute to negative impact on OHRQoL. These physical and emotional conditions, together with biological pathways, should receive more attention in treatment plans, in order to improve the patients' quality of life.
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