Evidence map›Paper›PMID 32666318›Full record

ArticleEuropean radiology2020

Diffusion tensor imaging of the anterior cruciate ligament graft following reconstruction: a longitudinal study.

Pieter Van Dyck, Thibo Billiet, Damien Desbuquoit, Peter Verdonk, Christiaan H Heusdens, Ella Roelant, Jan Sijbers, Martijn Froeling

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Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Pieter Van DyckDepartment of Radiology, Antwerp University Hospital and University of Antwerp, Wilrijkstraat 10, 2650, Edegem, Belgium. pieter.van.dyck@uza.be.ORCID https://orcid.org/0000-0001-7777-6008
Thibo BillietIcometrix, Kolonel Begaultlaan 1b, 3012, Leuven, Belgium.
Damien DesbuquoitDepartment of Radiology, Antwerp University Hospital and University of Antwerp, Wilrijkstraat 10, 2650, Edegem, Belgium.
Peter VerdonkMonica Orthopedic Research (MoRe) Foundation, Monica Hospital, Stevenslei 20, 2100, Deurne, Belgium.
Christiaan H HeusdensDepartment of Orthopedics, Antwerp University Hospital and University of Antwerp, Wilrijkstraat 10, 2650, Edegem, Belgium.
Ella RoelantClinical Trial Center (CTC), CRC Antwerp, Antwerp University Hospital and University of Antwerp, Wilrijkstraat 10, 2650, Edegem, Belgium.
Jan SijbersImec-Vision Lab, Department of Physics, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium.
Martijn FroelingDepartment of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0003-3841-0497
University of Antwerp · BEHeidelberg University · DEIcometrix (Belgium) · BE

Funding

Fonds Wetenschappelijk Onderzoek 1831217NFonds Wetenschappelijk Onderzoek T001017N
6 · The paper itself

Abstract

objectiveTo longitudinally monitor remodeling of human autograft following anterior cruciate ligament (ACL) reconstruction with DTI.

methodsTwenty-eight patients underwent DTI follow-up at 3, 8, and 14 months after clinically successful ACL reconstruction with tendon autograft. Among these, 18 patients had a concomitant lateral extra-articular procedure (LET). DTI data from 7 healthy volunteers was also obtained. Diffusion parameters (fractional anisotropy, FA; mean diffusivity, MD; axial diffusivity, AD; and radial diffusivity, RD) were evaluated within the fiber tractography volumes of the ACL graft and posterior cruciate ligament (PCL) in all patients. Data were analyzed using a linear mixed-effects model with post hoc testing using Bonferroni-Holm correction for multiple testing. The effect of additional LET was studied.

resultsThe ACL graft showed a significant decrease of FA over time (F = 4.00, p = 0.025), while the diffusivities did not significantly change over time. For PCL there were no significant DTI changes over time. A different evolution over time between patients with and without LET was noted for all diffusivity values of the ACL graft with reduced AD values in patients with LET at 8 months postoperatively (p = 0.048; adjusted p = 0.387). DTI metrics of the ACL graft differed largely from both native ACL and tendon at 14 months postoperatively.

conclusionOur study has shown the potential of DTI to longitudinally monitor the remodeling process in human ACL reconstruction. DTI analysis indicates that graft remodeling is incomplete at 14 months postoperatively. KEY POINTS: • DTI can be used to longitudinally monitor the remodeling process in human ACL reconstruction. • DTI analysis indicates that autograft remodeling is incomplete at 14 months postoperatively. • DTI may be helpful for evaluating new ACL treatments.

Indexed as

Anterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionAnterior Cruciate LigamentDiffusion Tensor ImagingHumansLongitudinal StudiesAnterior cruciate ligament reconstructionAutograftsDiffusion tensor imagingFollow-up studiesHumans

Identifiers

PMID32666318
OpenAlexW3043666622

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.