Evidence map›Paper›PMID 32666311›Full record

ArticleEJNMMI research2020

Detection limit of

Laura M Lechermann, Roido Manavaki, Bala Attili, Doreen Lau, Lorna B Jarvis, Tim D Fryer, Nick Bird, Luigi Aloj, Neel Patel, Bristi Basu and 4 more

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. In vivo tracking of ex-vivo-generatedMolecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. First-in-human infection imaging withFrontiers in nuclear medicine · 2024
    Article
  7. Direct Cell Radiolabeling forChemical reviews · 2022
    Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Laura M LechermannDepartment of Radiology, University of Cambridge, Cambridge, UK. lmtl2@cam.ac.uk.ORCID http://orcid.org/0000-0002-2742-6269
Roido ManavakiDepartment of Radiology, University of Cambridge, Cambridge, UK.
Bala AttiliDepartment of Radiology, University of Cambridge, Cambridge, UK.
Doreen LauDepartment of Radiology, University of Cambridge, Cambridge, UK.
Lorna B JarvisDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Tim D FryerWolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK.
Nick BirdDepartment of Nuclear Medicine, Addenbrooke's Hospital, Cambridge, UK.
Luigi AlojDepartment of Radiology, University of Cambridge, Cambridge, UK.
Neel PatelWolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK.
Bristi BasuDepartment of Oncology, University of Cambridge, Cambridge, UK.
Matthew ClevelandGSK Medicines Research Centre, Gunnels Wood Road, Stevenage, UK.
Franklin I AigbirhioWolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK.
Joanne L JonesDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Ferdia A GallagherDepartment of Radiology, University of Cambridge, Cambridge, UK. fag1000@cam.ac.uk.
University of Cambridge · GBAddenbrooke's Hospital · GBAge UK · GB

Funding

Cancer Research UK 16628Cancer Research UK 27150Cancer Research UK C19212/A16628Cancer Research UK C19212/A911376Wellcome TrustWellcome Trust -
6 · The paper itself

Abstract

purposeTracking cells in vivo using imaging can provide non-invasive information to understand the pharmacology, efficacy, and safety of novel cell therapies. Zirconium-89 (t

methodsJurkat T cells were labeled with varying concentrations of [

resultsUsing this in vitro model, the lowest cell number that could be visualized on 6-well plate images was 6.8 × 10

conclusionThe results show the feasibility of detecting [

Indexed as

Cell labelingCell trackingDetection limitPETZirconium-89

Identifiers

PMID32666311
PMCPMC7360010
OpenAlexW3042548894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.