ReviewCerebellum (London, England)2020
Essential Tremor Within the Broader Context of Other Forms of Cerebellar Degeneration.
Review in Cerebellum (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Pathophysiology of Cerebellar Tremor: The Forward Model-Related Tremor and the Inferior Olive Oscillation-Related Tremor.Frontiers in neurology · 2021Pooled it
- Purkinje Cell Loss and Changes in Basket Cell Morphology in Essential Tremor and Other Cerebellar Degenerative Diseases: A Postmortem Study of 332 Brains.Cerebellum (London, England) · 2026Article
- Spinocerebellar Ataxia Type 12: Spectrums of Movement Disorders and Clinical Features.Neuro-degenerative diseases · 2026Review
- Machine Learning Aided Kinematic Profiling of Reaching Movements Separates Spinocerebellar Ataxia type 12 and Essential Tremor.Cerebellum (London, England) · 2026Article
- Viral vector-mediated SLC9A6 gene replacement reduces cerebellar motor and molecular abnormalities in the shaker rat model of Christianson syndrome.Human molecular genetics · 2026Article
- Intention Tremor Severity Trajectory: Results from a Prospective Longitudinal Study of Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Observational
- Disorders of the Basal Ganglia and Cerebellum: A Comprehensive Review of Speech Sensorimotor Symptoms and Responses to Feedback Perturbations.Neurobiology of language (Cambridge, Mass.) · 2026Review
- Perceptual and Acoustical Features of Dysarthria in Essential Tremor: An Observational Study that Expands the Cerebellar Features of Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Observational
- Article
- Treatment of neurological pathology and inflammation in Machado-Joseph disease through in vivo self-assembled siRNA.Brain : a journal of neurology · 2025Article
- Emerging Deep Brain Stimulation Targets in the Cerebellum for Tremor.Cerebellum (London, England) · 2025Review
- Neuropsychiatric Approaches to Essential and Functional Tremor: A Comparative Study.Neuropsychiatric disease and treatment · 2025Article
- Erroneous Compensation for Long-Latency Feedback Delays as Origin of Essential Tremor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Decreased Synaptic Vesicle Glycoprotein 2A Binding in the Human Postmortem Essential Tremor Cerebellum: Evidence of Reduction in Synaptic Density.Cerebellum (London, England) · 2024Article
- Early-onset familial essential tremor is associated with nucleotide expansions of spinocerebellar ataxia in China.Molecular biology reports · 2024Article
- Featuring the Features of the Featureless Tremor: A Statement about Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Six Myths and Misconceptions about Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Review
- Research hotspots and frontiers of essential tremor from 2013 to 2023: a visualization analysis based on CiteSpace.Frontiers in aging neuroscience · 2024Review
- Does Head Tremor Predict Postural Instability After Bilateral Thalamic Stimulation in Essential Tremor?Cerebellum (London, England) · 2023Article
- Visuomotor Adaptation Deficits in Patients with Essential Tremor.Cerebellum (London, England) · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Essential tremor (ET) has recently been reconceptualized by many as a degenerative disease of the cerebellum. Until now, though, there has been no attempt to frame it within the context of these diseases. Here, we compare the clinical and postmortem features of ET with other cerebellar degenerations, thereby placing it within the broader context of these diseases. Action tremor is the hallmark feature of ET. Although often underreported in the spinocerebellar ataxias (SCAs), action tremors occur, and it is noteworthy that in SCA12 and 15, they are highly prevalent, often severe, and can be the earliest disease manifestation, resulting in an initial diagnosis of ET in many cases. Intention tremor, sometimes referred to as "cerebellar tremor," is a common feature of ET and many SCAs. Other features of cerebellar dysfunction, gait ataxia and eye motion abnormalities, are seen to a mild degree in ET and more markedly in SCAs. Several SCAs (e.g., SCA5, 6, 14, and 15), like ET, follow a milder and more protracted disease course. In ET, numerous postmortem changes have been localized to the cerebellum and are largely confined to the cerebellar cortex, preserving the cerebellar nuclei. Purkinje cell loss is modest. Similarly, in SCA3, 12, and 15, Purkinje cell loss is limited, and in SCA12 and 15, there is preservation of cerebellar nuclei and relative sparing of other central nervous system regions. Both clinically and pathologically, there are numerous similarities and intersection points between ET and other disorders of cerebellar degeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.