ArticleEuropean journal of pediatrics2020
Neurodevelopmental outcomes after moderate to severe neonatal hypoglycemia.
Article in European journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Neurocognitive Outcomes at Age 2 Years After Neonatal Hypoglycemia in a Cohort of Participants From the hPOD Randomized Trial.JAMA network open · 2022Trial
- The Evidence Informing Hypoglycaemia Treatment Thresholds in Asymptomatic, Term, Well Newborns: A Review of Literature and Critical Appraisal of Methodological Challenges.Journal of human lactation : official journal of International Lactation Consultant Association · 2026Review
- Neonatal hypoglycemia and neurodevelopment outcomes among late preterm infants: a prospective cohort study.Pediatric research · 2026Article
- Microstructural white matter changes in infants with transient neonatal hypoglycemia revealed by diffusion tensor imaging: a preliminary cross-sectional study.Quantitative imaging in medicine and surgery · 2026Article
- Task-free functional connectivity changes before and after hyper- and hypoglycemia in very preterm neonates.Neurophotonics · 2026Article
- [Expert consensus on the diagnosis and treatment of common neonatal diseases in primary healthcare institutions: neonatal hypoglycemia (2025)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Investigating brain haemodynamics during hypoglycaemia in very preterm neonates using diffuse optical tomography.medRxiv : the preprint server for health sciences · 2025Article
- Neonatal Hypoglycemia and Long-Term Pediatric Neurodevelopmental Outcomes: A Systematic Review.Cureus · 2025Review
- Exploring the long-term impacts of neonatal hypoglycemia to determine a safe threshold for glucose concentrations.European journal of pediatrics · 2025Review
- Writhing Movements and Hypoglycemia in Moderate-Late Preterm Infants: A Prospective Cohort Study.Children (Basel, Switzerland) · 2025Article
- Determining Potential Risk Factors for Epilepsy in Children with Neonatal Hypoglycemia.Iranian journal of child neurology · 2025Article
- Early hypoglycemia is not an independent risk factor for 2-year cognitive impairment in small for gestational age preterm infants of less than 32 weeks.European journal of pediatrics · 2024Article
- Neonatal Hypoglycemia and Neurodevelopmental Outcomes-An Updated Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2024Review
- Effect of recurrent severe insulin-induced hypoglycemia on the cognitive function and brain oxidative status in the rats.Diabetology & metabolic syndrome · 2024Article
- Transitional Neonatal Hypoglycemia and Adverse Neurodevelopment in Midchildhood.JAMA network open · 2024Article
- The Relationship between General Movements and Risk Factors in Moderate-Late Preterm Infants: A Prospective Cohort Study.Journal of clinical medicine · 2023Article
- Executive function and behaviour problems in school-age children born at risk of neonatal hypoglycaemia.Developmental medicine and child neurology · 2023Article
- Neonatal hypoglycemia: lack of evidence for a safe management.Frontiers in endocrinology · 2023Review
- Risk of hypoglycemia by anthropometric measurements in neonates of mothers with diabetes.European journal of pediatrics · 2022Article
- Cerebral Effects of Neonatal Dysglycemia.Clinics in perinatology · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The long-term consequences of transient neonatal hypoglycemia are sparsely studied. We performed a follow-up of a cohort of neonates with blood glucose recordings < 1.7 mmol/L (< 30 mg/dL), treated with > 2.5 mmol/L (> 45 mg/dL), compared with healthy siblings. Exclusion criteria were gestational age < 35 weeks, severe asphyxia, head injury, and other cerebral diseases. In 71 children with neonatal hypoglycemia and 32 control siblings, Wechsler IV cognitive test, Movement ABC-2 test, and Child Behavior Checklist were performed at mean age 7.75 and 9.17 years, respectively. No significant changes were detected for cognitive function by using Wechsler IV or for behavior by using Child Behavior Checklist. In univariate analysis, the hypoglycemia group had lower age-adjusted fine motor scores by using the Movement ABC-2 test compared with control siblings, 42.6 ± 31.2 vs. 57.2 ± 30.8 percentile (p = 0.03). In the sibling-paired analysis, the decrease in total motor score was highly significant, p = 0.009, driven by a decrease in fine motor score, p = 0.008. In the hypoglycemia group, adjusted analysis showed a lower fine motor function for boys, β = - 16.4, p = 0.048.Conclusion: Neonatal hypoglycemia treated with > 2.5 mmol/L was associated with lower fine motor scores within the normal range, particularly in boys. No associations with cognitive function or behavior were detected. What is Known: • Transient neonatal hypoglycemia is associated with acute neurologic dysfunction and long-term neurodevelopment impairment in 18 months of age. What is New: • Neonatal hypoglycemia treated with > 2.5 mmol/L is associated with lower fine motor function within the normal range, particularly in boys, but not to changes in cognitive function or behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.