Evidence map›Paper›PMID 32666227›Full record

ArticleMolecular neurobiology2020

CDK4 and CDK5 Inhibition Have Comparable Mild Hypothermia Effects in Preventing Drp1-Dependent Mitochondrial Fission and Neuron Death Induced by MPP

Shang-Hsun Yang, Chiu-Ying Huang, Chia-Yun Hsieh, Jih-Ing Chuang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Three decades of Cdk5.Journal of biomedical science · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shang-Hsun YangDepartment of Physiology, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan, Republic of China.
Chiu-Ying HuangDepartment of Physiology, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan, Republic of China.
Chia-Yun HsiehDepartment of Physiology, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan, Republic of China.
Jih-Ing ChuangDepartment of Physiology, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan, Republic of China. jichuang@mail.ncku.edu.tw.ORCID http://orcid.org/0000-0002-4977-2293
National Cheng Kung University · TW

Funding

Ministry of Science and Technology, Taiwan MOST 105-2320-B-006 -042 -MY3National Science Council NSC 102-2320-B-006 -012 -MY3
6 · The paper itself

Abstract

Mild hypothermia has promising effects in the treatment of acute brain insults and also affects cell cycle progression. Mitochondrial dynamics, fusion and fission, are changed along with the cell cycle and disrupted in neurodegenerative diseases, including Parkinson's disease (PD). However, the effects of hypothermia on aberrant mitochondrial dynamics in PD remain unknown. We hypothesized that mild hypothermia protects neurons by regulating cell cycle-dependent protein expression and mitochondrial dynamics in a 1-methyl-4-phenylpyridinium (MPP

Indexed as

Hypothermia, InducedMitochondrial Dynamics1-Methyl-4-phenylpyridiniumAnimalsCell Cycle ProteinsCell DeathCell Line, TumorCell ProliferationCerebral CortexCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 5Cyclin-Dependent Kinase Inhibitor p27DynaminsHumansMitochondriaNeurons1-Methyl-4-phenylpyridiniumCell Cycle ProteinsCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 5Cyclin-Dependent Kinase Inhibitor p27Dnm1l protein, ratDynaminsNeuroprotective AgentsProtein Kinase InhibitorsRoscovitineCDK4CDK5Drp1Mild hypothermiaMitochondrial fissionParkinson’s disease

Identifiers

PMID32666227
OpenAlexW3043501253

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.