SynthesisSocial psychiatry and psychiatric epidemiology2020
Social inequalities in antidepressant treatment outcomes: a systematic review.
Synthesis in Social psychiatry and psychiatric epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Depressive disorders: systematic review of approved psychiatric medications (2009-April 2025) and pipeline phase 3 medications.BMC psychiatry · 2025Pooled it
- Initiation of antidepressant medicines in Swedish patients diagnosed with COVID-19: a registry-based cohort study.Social psychiatry and psychiatric epidemiology · 2026Article
- Individual Socioeconomic Measures and Change in HoNOS Scores among Persons Attending Adult Community Mental Health Services.Community mental health journal · 2026Article
- Socioeconomic Status Is Associated With Reward Processing, Interleukin 1β, Striatal Connectivity, and Antidepressant Outcomes in Individuals With Major Depressive Disorder: A CAN-BIND-1 Report.Biological psychiatry global open science · 2026Article
- Parsing Socioeconomic Effects on Treatment Trajectory and Reward Processing in Depression.Biological psychiatry global open science · 2026Article
- A Framework to Quantify Disparities in Pharmacogenomic Treatment Concordance and Drug Response Outcomes.Clinical and translational science · 2026Article
- A Pilot Study: Comparative Effects of Green Tea Extract and Duloxetine on Oxaliplatin-Induced Allodynia in a Murine Model.Metabolites · 2025Article
- A Framework to Quantify Disparities in Pharmacogenomic Treatment Concordance and Drug Response Outcomes.medRxiv : the preprint server for health sciences · 2025Article
- Does change in area-level deprivation, change health outcomes? A latent class growth analysis of population data.SSM - population health · 2025Article
- Antidepressant Switching as a Proxy Phenotype for Drug Nonresponse: Investigating Clinical, Demographic, and Genetic Characteristics.Biological psychiatry global open science · 2025Article
- The Impact of Antidepressants on Surgical Outcomes Among Patients With Abdominal Cancer and Comorbid Depression.Psycho-oncology · 2025Article
- Socioeconomic and spatial distribution of depressive symptoms and access to treatment in Peru: A repeated nationwide cross-sectional study from 2014 to 2021.SSM - population health · 2025Article
- Maternal and pregnancy factors contributing to the association between area deprivation and infant mortality in England: a retrospective cohort study.The Lancet regional health. Europe · 2024Article
- Efficacy and safety of a mineral and vitamin treatment on symptoms of antenatal depression: 12-week fully blinded randomised placebo-controlled trial (NUTRIMUM).BJPsych open · 2024Article
- Overadjustment bias in systematic reviews and meta-analyses of socio-economic inequalities in health: a meta-research scoping review.International journal of epidemiology · 2024Article
- Unemployment and underemployment are causes of suicide.Science advances · 2023Article
- Bringing an end to the silence: identifying priorities and solutions to addressing the mental health consequences of child marriage.Health policy and planning · 2023Article
- A cultural-ecosocial systems view for psychiatry.Frontiers in psychiatry · 2023Article
- Associations of Migration, Socioeconomic Position and Social Relations With Depressive Symptoms - Analyses of the German National Cohort Baseline Data.International journal of public health · 2023Article
- COVID-19 mental health impact and responses in low-income and middle-income countries: reimagining global mental health.The lancet. Psychiatry · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo identify, review and synthesize evidence on whether social disadvantage moderates antidepressant treatment outcomes, even when access to treatment is not a consideration.
methodsThe systematic review was done in accordance with PRIMSA guidelines. An a priori systematic search strategy was used to search databases (MEDLINE, PsychINFO, EMBASE, Global Health and Cochrane Trials Library) from their earliest entries through December 31, 2018. A two-step screening procedure was followed, and all experimental studies of antidepressant treatment in ICD/DSM diagnosed cases of depression were included. Studies with subjects < 18 years or investigating other modalities of treatment were excluded.
resultsThirteen papers reporting analyses from nine studies met inclusion criteria. There was heterogeneity in sample sizes, target populations, treatment settings, clinical outcomes and definition of SES indices. The primary outcome was the relative effect of socioeconomic status (SES) (as measured by income, employment status and level of education)-on antidepressant treatment outcomes.
conclusionsThe evidence from this review suggests that lower SES may lead to social inequalities in antidepressant treatment outcomes even in the context of clinical trials in which all participants have equal access to the same high-quality, standardized care. The review calls for more careful consideration of the choice and operationalization of SES indicators, and the need to "employ sampling methods that ensure ample representation of individuals from a wide range of social worlds". The review concludes with tentative suggestions about how to reduce social inequalities in antidepressant treatment outcomes at the level of individuals and populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.