ArticleClinical rheumatology2021
Cardiac valvular involvement of Takayasu arteritis.
Article in Clinical rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Prevalence and clinical severity of takayasu arteritis angiographic types: a systematic review with meta-analysis.Rheumatology international · 2025Pooled it
- Article
- "Severe Aortic Regurgitation as the Initial Manifestation of Takayasu Arteritis in a Young Woman: A Case Report".Case reports in medicine · 2026Article
- Long-term outcomes of aortic valve insufficiency in patients with Takayasu arteritis.Frontiers in immunology · 2025Article
- A challenging case of Takayasu's arteritis in a young male with various manifestations and poor outcome.BMC cardiovascular disorders · 2024Article
- Review
- Age, sex and angiographic type-related phenotypic differences in inpatients with Takayasu arteritis: A 13-year retrospective study at a national referral center in China.Frontiers in cardiovascular medicine · 2023Article
- [Takayasu's disease: an underdiagnosed entity in Sub-Saharan Africa. Report of five Gabonese cases].Medecine tropicale et sante internationale · 2022Article
- Risk factors and surgical prognosis in patients with aortic valve involvement caused by Takayasu arteritis.Arthritis research & therapy · 2022Article
- Risk factors of aortic regurgitation progression in Chinese patients with Takayasu's arteritis: a prospective cohort study.Therapeutic advances in chronic disease · 2022Article
- Novel Therapies in Takayasu Arteritis.Frontiers in medicine · 2021Review
- Echocardiographic evaluation of Takayasu arteritis including speckled tracking echocardiography and aortic stiffness.Indian heart journalArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveThis study aimed to investigate the imaging and serological features in Takayasu arteritis (TA) patients with valvular involvement and determine the relationship between them.
methodThis is a retrospective single-center study enrolled 103 TA patients fulfilling the American College of Rheumatology criteria. An independent medical chart review was performed by two senior rheumatologists from Beijing Anzhen Hospital, Capital Medical University. The logistic analysis was used to investigate the relationship between valvular involvement in TA patients and the imaging and serological features of them.
resultsSixty-six TA patients (64.08%) had cardiac valvular involvement in our study. Aortic insufficiency (62.12%) was the most common valvular involvement. Twelve (22.22%) patients developed heart failure. In patients with valvular involvement, the most common angiographic type was Numano type V, which was significantly higher than that in patients without valvular involvement (53.30% vs 32.43%, p = 0.044), followed by coronary involvement (28.79% vs 10.81%, p = 0.036) and Numano type IIb (21.21% vs 5.41%, p = 0.034). Serum levels of immunoglobulin A (2.84 ± 1.42 g/L vs 2.26 ± 0.97 g/L, p = 0.032) and immunoglobulin G (13.5 ± 4.71 g/L vs 11.42 ± 3.01 g/L, p = 0.015) were significantly higher in patients with valvular involvement. Numano type IIb is significantly related to moderate-severe aortic valvular regurgitation in TA patients (4.10 [1.03-16.33], p = 0.04). Elevated C-reactive protein (CRP) level is associated with moderate-severe mitral valve involvement in TA patients (p = 0.05, OR = 17.75, 95% CI 1.07-295.41).
conclusionsCRP elevation and Numano type IIb are significantly related to different types of valvular involvement in TA patients. Key Points • The Numano types IIb and V were common in TA patients with valvular involvement. • CRP elevation and Numano type IIb are close related to valvular involvement in TA patient. • Echocardiogram screening and CRP level examination are reasonable to TA patients which might have valvular involvement.
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