Evidence map›Paper›PMID 32666137›Full record

ReviewRheumatology international2020

Autoimmune and rheumatic musculoskeletal diseases as a consequence of SARS-CoV-2 infection and its treatment.

Sanket Shah, Debashish Danda, Chengappa Kavadichanda, Saibal Das, M B Adarsh, Vir Singh Negi

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Rheumatology international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06460168 (Comparative Effects of Mulligan and Maitland Techniques on Pain, Range of Motion and Functional Disability in Post Prp Knee Osteoarthritis), which is not on this map. Cited by 76 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 3 pooled it
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06460168 nacompletednot on this mapstarted 2024, after this paper: background citation

Comparative Effects of Mulligan and Maitland Techniques on Pain, Range of Motion and Functional Disability in Post Prp Knee Osteoarthritis

TypeinterventionalSponsorRiphah International UniversityRan2024 to 2025Enrolled36ConditionsKnee OsteoarthritisArmsMulligan(MWM) MobilizationTechnique, Maitland Mobilization technique
3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 3 syntheses or guidelines pooled it, 127 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Article
  7. Musculoskeletal Symptoms and Post-COVID Functional Status among COVID-19 Survivors: A Single-Center Prospective Observational Study.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Inflammatory Arthritis After COVID-19: A Case Series.The American journal of case reports · 2023
    Article
  20. Observational

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sanket ShahDepartment of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.ORCID 0000-0003-3224-1151
Debashish DandaDepartment of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, India.ORCID 0000-0002-2121-0942
Chengappa KavadichandaDepartment of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.ORCID 0000-0002-3643-3989
Saibal DasDepartment of Clinical Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.ORCID 0000-0002-3153-4166
M B AdarshDepartment of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.ORCID 0000-0001-8091-1952
Vir Singh NegiDepartment of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India. vsnegi22@yahoo.co.in.ORCID 0000-0003-1518-6031
Jawaharlal Institute of Post Graduate Medical Education and Research · INChristian Medical College, Vellore · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus disease-2019 (COVID-19) pandemic is likely to pose new challenges to the rheumatology community in the near and distant future. Some of the challenges, like the severity of COVID-19 among patients on immunosuppressive agents, are predictable and are being evaluated with great care and effort across the globe. A few others, such as atypical manifestations of COVID-19 mimicking rheumatic musculoskeletal diseases (RMDs) are being reported. Like in many other viral infections, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can potentially lead to an array of rheumatological and autoimmune manifestations by molecular mimicry (cross-reacting epitope between the virus and the host), bystander killing (virus-specific CD8 + T cells migrating to the target tissues and exerting cytotoxicity), epitope spreading, viral persistence (polyclonal activation due to the constant presence of viral antigens driving immune-mediated injury) and formation of neutrophil extracellular traps. In addition, the myriad of antiviral drugs presently being tried in the treatment of COVID-19 can result in several rheumatic musculoskeletal adverse effects. In this review, we have addressed the possible spectrum and mechanisms of various autoimmune and rheumatic musculoskeletal manifestations that can be precipitated by COVID-19 infection, its therapy, and the preventive strategies to contain the infection.

Indexed as

Antibodies, AntinuclearAntibodies, AntiphospholipidAntiviral AgentsArthralgiaAutoimmune DiseasesBetacoronavirusBlood Coagulation DisordersCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentCross ReactionsExtracellular TrapsFibrin Fibrinogen Degradation ProductsGuillain-Barre SyndromeHumansLupus Coagulation InhibitorAntibodies, AntinuclearAntibodies, AntiphospholipidAntiviral AgentsFibrin Fibrinogen Degradation Productsfibrin fragment DLupus Coagulation InhibitorAutoimmunityCoronavirus disease-2019 (COVID-19)Rheumatic musculoskeletal diseases (RMDs)Rheumatology

Identifiers

PMID32666137
PMCPMC7360125
OpenAlexW3043589636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.