Evidence map›Paper›PMID 32666076›Full record

ArticleInternational journal of epidemiology2021

Parental occupational exposure pre- and post-conception and development of asthma in offspring.

Kathrine Pape, Cecile Svanes, Camilla S Sejbæk, Andrei Malinovschi, Byndis Benediktsdottir, Bertil Forsberg, Christer Janson, Geza Benke, Gro Tjalvin, José Luis Sánchez-Ramos and 14 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?International journal of environmental research and public health · 2021
    Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 17 institutions in 7 countries.

Kathrine PapeNational Research Center for the Working Environment, Copenhagen, Denmark.
Cecile SvanesCentre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Camilla S SejbækNational Research Center for the Working Environment, Copenhagen, Denmark.
Andrei MalinovschiDepartment of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden.
Byndis BenediktsdottirDepartment of Allergy, Respiratory Medicine and Sleep, Landspitali University Hospital, Reykjavik, Iceland.
Bertil ForsbergSection of Sustainable Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Christer JansonDepartment of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
Geza BenkeDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.
Gro TjalvinDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
José Luis Sánchez-RamosDepartment of Nursing, University of Huelva. Avenida Tres de Marzo, s/n 21071, Huelva, Spain.
Jan-Paul ZockISGlobal, Barcelona, Spain.
Kjell TorenDepartment of Public Health and Community Medicine at Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Lennart BråbäckSection of Sustainable Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Mathias HolmDepartment of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
Rain JõgiTartu University Hospital, Lung Clinic, Tartu, Estonia.
Randi J BertelsenDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Thorarin GíslasonDepartment of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden.
Torben SigsgaardDepartment of Public Health, Environment, Work and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark.
Xiaoqin LiuThe National Centre for Register-based Research, Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark.
Karin S HougaardNational Research Center for the Working Environment, Copenhagen, Denmark.
Ane JohannessenCentre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Caroline LodgeMelbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
Shyamali C DharmageMelbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
Vivi SchlünssenNational Research Center for the Working Environment, Copenhagen, Denmark.
Aarhus University · DKReykjavík University · ISThe University of Melbourne · AUUmeå University · SEUniversity of Bergen · NOUppsala University · SEHaukeland University Hospital · NOMonash University · AUNational Research Centre for the Working Environment · DKSahlgrenska University Hospital · SETartu University Hospital · EEUniversidad de Huelva · ESUniversitat Pompeu Fabra · ESUniversity of Copenhagen · DKUniversity of Gothenburg · SEUniversity of Iceland · ISWestern Norway University of Applied Sciences · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhile direct effects of occupational exposures on an individual's respiratory health are evident, a new paradigm is emerging on the possible effects of pre-conception occupational exposure on respiratory health in offspring. We aimed to study the association between parental occupational exposure starting before conception and asthma in their offspring (at 0-15 years of age).

methodsWe studied 3985 offspring participating in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study. Their mothers or fathers (n = 2931) previously participated in the European Community Respiratory Health Survey (ECRHS). Information was obtained from questionnaires on parental job history pre- and post-conception which was linked to an asthma-specific job-exposure matrix (JEM). We assessed the association between parental occupational exposure and offspring asthma, applying logistic regression models, clustered by family and adjusted for study centre, offspring sex, parental characteristics (age, asthma onset, place of upbringing, smoking) and grandparents' level of education.

resultsParental occupational exposure to microorganisms, pesticides, allergens or reactive chemicals pre-conception or both pre- and post-conception was not related to offspring asthma; in general, subgroup analyses confirmed this result. However, maternal exposure both pre- and post-conception to allergens and reactive chemicals was associated with increased odds for early-onset asthma in offspring (0-3 years of age); odds ratio 1.70 (95% CI: 1.02-2.84) and 1.65 (95% CI: 0.98-2.77), respectively.

conclusionsThis study did not find evidence that parental occupational exposure, defined by an asthma JEM before conception only or during pre- and post-conception vs non-exposed, was associated with offspring asthma.

Indexed as

AsthmaOccupational ExposureAustraliaEuropeFemaleHumansParentsRisk FactorsSpainair pollutantsasthmaEpidemiologygeneration studyjob-exposure matricesoccupationoccupational exposure

Identifiers

PMID32666076
PMCPMC7825962
OpenAlexW3043015179

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.