ArticleResearch (Washington, D.C.)2020
Magnetic Micromanipulation for
Article in Research (Washington, D.C.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Failure of morphogenesis in chronic inflammation-associated early tumourigenesis: Extracellular matrix biomechanics as an integrative layer.Biochemistry and biophysics reports · 2026Review
- Drop-Shaped Optical Microfiber Enabled Biomechanical Sensor.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tumor Development in Ulcerative Colitis: Perspectives From Biomechanical Characteristics.Development, growth & differentiation · 2025Review
- A thermodynamic perspective on mammalian neural crest ingression.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Tissue stiffness mapping by light sheet elastography.Science advances · 2025Article
- Probabilistic analysis of spatial viscoelastic cues in 3D cell culture using magnetic microrheometry.Biophysical journal · 2025Article
- Apico-basal intercalations enable the integrity of curved epithelia.Computational and structural biotechnology journal · 2025Article
- Passive biaxial mechanical properties of sheep myocardium.Frontiers in bioengineering and biotechnology · 2025Article
- A fibronectin gradient remodels mixed-phase mesoderm.Science advances · 2024Article
- Boundarics in Biomedicine.Research (Washington, D.C.) · 2024Review
- Spreadable Magnetic Soft Robots with On-Demand Hardening.Research (Washington, D.C.) · 2023Article
- Extracellular Matrix in Human Craniofacial Development.Journal of dental research · 2022Review
- In vivo acoustic manipulation of microparticles in zebrafish embryos.Science advances · 2022Article
- Squeezing the eggs to grow: The mechanobiology of mammalian folliculogenesis.Frontiers in cell and developmental biology · 2022Review
- A Two-Axis Piezoresistive Force Sensing Tool for Microgripping.Sensors (Basel, Switzerland) · 2021Article
- Towards a Comprehensive and Robust Micromanipulation System with Force-Sensing and VR Capabilities.Micromachines · 2021Article
- FACEts of mechanical regulation in the morphogenesis of craniofacial structures.International journal of oral science · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanical properties of tissues are pivotal for morphogenesis and disease progression. Recent approaches have enabled measurements of the spatial distributions of viscoelastic properties among embryonic and pathological model systems and facilitated the generation of important hypotheses such as durotaxis and tissue-scale phase transition. There likely are many unexpected aspects of embryo biomechanics we have yet to discover which will change our views of mechanisms that govern development and disease. One area in the blind spot of even the most recent approaches to measuring tissue stiffness is the potentially anisotropic nature of that parameter. Here, we report a magnetic micromanipulation device that generates a uniform magnetic field gradient within a large workspace and permits measurement of the variation of tissue stiffness along three orthogonal axes. By applying the device to the organ-stage mouse embryo, we identify spatially heterogenous and directionally anisotropic stiffness within the mandibular arch. Those properties correspond to the domain of expression and the angular distribution of fibronectin and have potential implications for mechanisms that orient collective cell movements and shape tissues during development. Assessment of anisotropic properties extends the repertoire of current methods and will enable the generation and testing of hypotheses.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.