ArticleJournal of the Endocrine Society2020
The Relationship of Lean Body Mass With Aging to the Development of Diabetes.
Article in Journal of the Endocrine Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Unraveling the role of muscle mass and strength in predicting type 2 diabetes risk: a systematic review.Acta diabetologica · 2025Pooled it
- Association between body composition measured using Dual-Energy X-Ray absorptiometry and incident type 2 diabetes mellitus in adults: A systematic review.Journal of diabetes and metabolic disorders · 2025Review
- The Critical Role of Body Composition Assessment in Advancing Research and Clinical Health Risk Assessment across the Lifespan.Journal of obesity & metabolic syndrome · 2025Review
- Body Mass Index and Diabetes Incidence Across the Adult Lifespan: The Baltimore Longitudinal Study of Aging.Journal of the Endocrine Society · 2024Article
- Low muscle mass is associated with low insulin sensitivity, impaired pancreatic β cell function, and high glucose excursion in nondiabetic nonobese Japanese women.Metabolism open · 2024Article
- Relationship of endogenous plasma concentrations of β-hydroxy β-methyl butyrate (HMB) with frailty in community dwelling older adults with type-2 diabetes mellitus.The journal of nutrition, health & aging · 2024Article
- The Vicious Cycle of Type 2 Diabetes Mellitus and Skeletal Muscle Atrophy: Clinical, Biochemical, and Nutritional Bases.Nutrients · 2024Review
- Low muscle mass index is associated with type 2 diabetes risk in a Latin-American population: a cross-sectional study.Frontiers in nutrition · 2024Article
- The relationship between fat distribution and diabetes in US adults by race/ethnicity.Frontiers in public health · 2024Article
- Association of predicted fat mass and lean body mass with diabetes: a longitudinal cohort study in an Asian population.Frontiers in nutrition · 2023Article
- More appendicular lean mass relative to body mass index is associated with lower incident diabetes in middle-aged adults in the CARDIA study.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2023Article
- Prediabetes is an independent risk factor for sarcopenia in older men, but not in older women: the Bunkyo Health Study.Journal of cachexia, sarcopenia and muscle · 2022Article
- Longitudinal Associations of Air Pollution With Body Size and Composition in Midlife Women: The Study of Women's Health Across the Nation.Diabetes care · 2022Article
- Higher Muscle Mass Protects Women with Gestational Diabetes Mellitus from Progression to Type 2 Diabetes Mellitus.Diabetes & metabolism journal · 2022Article
- Association between muscle mass and diabetes prevalence independent of body fat distribution in adults under 50 years old.Nutrition & diabetes · 2022Article
- Association between fat mass index, fat-free mass index and hemoglobin A1c in a Japanese population: The Tohoku Medical Megabank Community-based Cohort Study.Journal of diabetes investigation · 2022Article
- Normalized Creatinine-to-Cystatin C Ratio and Risk of Diabetes in Middle-Aged and Older Adults: The China Health and Retirement Longitudinal Study.Diabetes & metabolism journal · 2022Article
- Article
- Urine creatinine concentration and clinical outcomes in older adults: The Cardiovascular Health Study.Journal of the American Geriatrics Society · 2021Article
- Association of Adherence to a Mediterranean Diet with Excess Body Mass, Muscle Strength and Physical Performance in Overweight or Obese Adults with or without Type 2 Diabetes: Two Cross-Sectional Studies.Healthcare (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
contextOlder adults have the greatest burden of diabetes; however, the contribution of age-related muscle loss to its development remains unclear.
objectiveWe assessed the relationship of lean body mass with aging to incident diabetes in community-dwelling adults. DESIGN AND
settingWe studied participants in the Baltimore Longitudinal Study of Aging with median follow-up of 7 years (range 1-16). Cox proportional hazard models with age as the time scale were used. Time-dependent lean body mass measures were updated at each follow-up visit available.
participantsParticipants included 871 men and 984 women without diabetes who had ≥ 1 assessment of body composition using dual x-ray absorptiometry. MAIN OUTCOMES: Incident diabetes, defined as self-reported history and use of glucose-lowering medications; or fasting plasma glucose ≥ 126 mg/dL and 2-hour oral glucose tolerance test glucose ≥ 200 mg/dL either at the same visit or 2 consecutive visits.
resultsThe baseline mean [standard deviation] age was 58.9 [17.3] years. Men and women with a higher percentage of total lean body mass had lower fasting and 2-hour glucose levels, and less prediabetes (all
conclusionsRelatively lower lean body mass with aging is associated with incident diabetes in men and partially related to anthropometrics, but not so in women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.