Evidence map›Paper›PMID 32665992›Full record

SynthesisInvestigative and clinical urology2020

Clinical correlation among male infertility and overall male health: A systematic review of the literature.

Francesco Del Giudice, Alex M Kasman, Matteo Ferro, Alessandro Sciarra, Ettore De Berardinis, Federico Belladelli, Andrea Salonia, Michael L Eisenberg

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Investigative and clinical urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  3. The Association Between Lipid Serum and Semen Parameters: a Systematic Review.Reproductive sciences (Thousand Oaks, Calif.) · 2023
    Pooled it
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  19. Proteostasis as a Sentry for Sperm Quality and Male Fertility.Advances in experimental medicine and biology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesco Del GiudiceDepartment of Maternal-Infant and Urological Sciences, "Sapienza" Rome University, Policlinico Umberto I Hospital, Rome, Italy.ORCID 0000-0003-3865-5988
Alex M KasmanDepartment of Urology, Stanford University School of Medicine, Stanford, CA, USA.
Matteo FerroDivision of Urology, European Institute of Oncology (IEO), Milan, Italy.ORCID 0000-0002-9250-7858
Alessandro SciarraDepartment of Maternal-Infant and Urological Sciences, "Sapienza" Rome University, Policlinico Umberto I Hospital, Rome, Italy.ORCID 0000-0002-7899-8056
Ettore De BerardinisDepartment of Maternal-Infant and Urological Sciences, "Sapienza" Rome University, Policlinico Umberto I Hospital, Rome, Italy.
Federico BelladelliDepartment of Urology, Stanford University School of Medicine, Stanford, CA, USA.
Andrea SaloniaUnit of Urology/Division of Oncology, IRCCS Ospedale San Rafaele, URI, Milan, Italy.ORCID 0000-0002-0595-7165
Michael L EisenbergDepartment of Urology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-5482-0141

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Ongoing evidence has suggested the role of male factor infertility as a potential predictor of mortality and general health status. The aim of the present review is to update the current knowledge base regarding the association between male factor infertility and general health through a critical review of the literature. Materials and Methods: A systematic review of the literature was carried out from inception to November 2019 in order to evaluate significant associations between male infertility and adverse health outcomes such as cardiovascular, oncologic, metabolic and autoimmune diseases as well as overall mortality. Results: In all, 27 studies met inclusion criteria and were critically examined. Five studies examined male infertility and cardiovascular disease risk, 11 examined oncologic risk (e.g., overall cancer risk, testis and prostate cancer), 8 examined aggregate chronic medical diseases and 5 infertility related to incidence of mortality, for a total of 599,807 men diagnosed with any male factor infertility covering a period from 1916 to 2016. Conclusions: A man's fertility and overall health appear to be interconnected. Therefore, a diagnosis of male infertility may allow a window into future comorbidity and/or mortality which may help guide clinical decisions and counseling. Several possible etiologies such as genetic, epigenetic, developmental, and lifestyle-based factors need to be further evaluated in order to establish the underlying mechanisms between male infertility and health.

Indexed as

Infertility, MaleMen's HealthCardiovascular DiseasesCorrelation of DataHumansMaleNeoplasmsAndrogensHealthHypogonadismInfertility, maleMortality

Identifiers

PMID32665992
PMCPMC7329649

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.