ArticleNPJ Parkinson's disease2020
Altered interhemispheric synchrony in Parkinson's disease patients with levodopa-induced dyskinesias.
Article in NPJ Parkinson's disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Functional motor network abnormalities associated with levodopa-induced dyskinesia in Parkinson's disease: A systematic review.NeuroImage. Clinical · 2024Pooled it
- Multimodal Neuroimaging Reveals Distinct Characteristics of Levodopa-Induced Dyskinesias in de novo Parkinson's Disease Patients.Brain topography · 2026Article
- Evaluation of glymphatic system activity and lateralization by diffusion tensor imaging in Parkinson's disease with excessive daytime sleepiness.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Effects of puerarin on gait disturbance in a 6-hydroxydopamine mouse model of Parkinson's disease.Pharmacological reports : PR · 2025Article
- Gray Matter Asymmetry Alterations in Patients With Spinocerebellar Ataxia Type 3: A Voxel-Based Morphometric Comparison Study.CNS neuroscience & therapeutics · 2024Article
- Distance-related functional reorganization predicts motor outcome in stroke patients.BMC medicine · 2024Observational
- Article
- Microstructural and functional alterations of the ventral pallidum are associated with levodopa-induced dyskinesia in Parkinson's disease.European journal of neurology · 2024Article
- Convergent and divergent intra- and internetwork connectivity in Parkinson's disease with wearing-off.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Location matters: altered interhemispheric homotopic connectivity in post-stroke dyskinesia.Frontiers in neurology · 2024Article
- Impaired Interhemispheric Synchrony in Parkinson's Disease with Fatigue.Journal of personalized medicine · 2022Article
- Altered functional connectivity of cerebellar dentate nucleus in peak-dose dyskinesia in Parkinson's disease.Frontiers in aging neuroscience · 2022Article
- Autopallidotomy: From Colloquial Term to Scientific Theory.Journal of Parkinson's disease · 2022Review
- Novel Non-invasive Transcranial Electrical Stimulation for Parkinson's Disease.Frontiers in aging neuroscience · 2022Review
- Altered Interhemispheric Functional Connectivity Associated With Early Verbal Fluency Decline After Deep Brain Stimulation in Parkinson's Disease.Frontiers in aging neuroscience · 2022Article
- The cross-hemispheric nigrostriatal pathway prevents the expression of levodopa-induced dyskinesias.Neurobiology of disease · 2021Article
- Prediction of Deep Brain Stimulation Outcome in Parkinson's Disease With Connectome Based on Hemispheric Asymmetry.Frontiers in neuroscience · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Levodopa-induced dyskinesias are common motor complication of Parkinson's disease after 4-6 years of treatment. The hallmarks of dyskinesias include unilateral onset and the tendency to appear on the more affected body sides. There is a growing literature documenting the lateralization abnormalities are associated with the emergence of dyskinesias. Our investigation aimed to explore interhemispheric functional and its corresponding morphological asymmetry. A total of 22 dyskinetic patients, 23 nondyskinetic patients, and 26 controls were enrolled. Resting-state functional magnetic resonance imaging scans were performed twice before and after dopaminergic medication. Voxel-mirrored Homotopic Connectivity (VMHC) and Freesurfer were employed to assess the synchronicity of functional connectivity and structural alternations between hemispheres. During OFF state, dyskinetic patients showed desynchronization of inferior frontal cortex (IFC) when compared to nondyskinetic patients. And during ON state, dyskinetic patients showed desynchronization of IFC and pre-supplementary motor area (pre-SMA) when compared to nondyskinetic patients. However, there was no corresponding significant asymmetries in cortical thickness. Moreover, the degree of desynchronization of IFC and pre-SMA in dyskinetic pateients during ON state were negatively correlated with the Abnormal Involuntary Movement Scale (AIMS) scores. Notably, among patients who showed asymmetrical dyskinesias, there was a significant negative correlation between VMHC values of IFC and dyskinesias symptom asymmetry. Our findings suggested that uncoordinated inhibitory control over motor circuits may underlie the neural mechanisms of dyskinesias in Parkinson's disease and be related to its severity and lateralization.
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