Evidence map›Paper›PMID 32665852›Full record

ReviewGastroenterology report2020

Influence of microbiota on immunity and immunotherapy for gastric and esophageal cancers.

Xiaoli Zhang, Zui Pan

Open access · diamondAbstract readReview
In one paragraph

Review in Gastroenterology report, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 31 citations in OpenAlex.

  1. Journal of gastrointestinal oncology · 2026
    Article
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  5. Review
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  15. Review
  16. Article
  17. Article
  18. Interdisciplinary insights into the link between gut microbiome and gastric carcinogenesis-what is currently known?Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2022
    Review
  19. The interplay betweenFrontiers in cellular and infection microbiology · 2022
    Review
  20. A new biological triangle in cancer: intestinal microbiota, immune checkpoint inhibitors and antibiotics.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Xiaoli ZhangDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
Zui PanCollege of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX, USA.ORCID 0000-0003-4105-901X
The Ohio State University · USThe University of Texas at Arlington · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Oncogenic Function of Ca2+ Channel Orai1 in Esophageal CarcinogenesisR01CA185055 · NCI · OHIO STATE UNIVERSITY · PI CHEN, TONG, PAN, ZUI · 2015 to 2019
$1.6M
An Inverted Nikon A1R Laser Scanning Confocal MicroscopeS10OD025230 · OD · UNIVERSITY OF TEXAS ARLINGTON · PI PAN, ZUI · 2019 to 2019
$449k
NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA185055NIH HHS S10 OD025230
6 · The paper itself

Abstract

Gastric and esophageal cancers are multifactorial and multistage-involved malignancy. While the impact of gut microbiota on overall human health and diseases has been well documented, the influence of gastric and esophageal microbiota on gastric and esophageal cancers remains unclear. This review will discuss the reported alteration in the composition of gastric and esophageal microbiota in normal and disease conditions, and the potential role of dysbiosis in carcinogenesis and tumorigenesis. This review will also discuss how dysbiosis stimulates local and systemic immunity, which may impact on the immunotherapy for cancer.

Indexed as

antibioticscheckpoint inhibitorsdysbiosisH. pyloriproton-pump inhibitorstumor microenvironment

Identifiers

PMID32665852
PMCPMC7333930
OpenAlexW3033246409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.