ArticleThe ISME journal2020
Genome wide transcriptomic analysis of the soil ammonia oxidizing archaeon Nitrososphaera viennensis upon exposure to copper limitation.
Article in The ISME journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Oxygen production as an electron overflow pathway in ammonia-oxidizing archaea.Science advances · 2026Article
- Copper requirements and copper toxicity as niche-defining factors in the growth of terrestrial ammonia-oxidizing archaea and bacteria.FEMS microbiology ecology · 2026Article
- Metabolic potential and contributions of ammonia-oxidizing microorganisms and complete ammonia oxidizers to soil nitrification in upland soils of northern China.ISME communications · 2026Article
- Environmental distribution, physiology and genomic adaptations of arctic ammonia-oxidizing archaea.Frontiers in microbiology · 2026Article
- Article
- Exploring proteinmBio · 2025Article
- Nitrous oxide production via enzymatic nitroxyl from the nitrifying archaeonProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Biofilm lifestyle across different lineages of ammonia-oxidizing archaea.The ISME journal · 2025Article
- Geno-pheno characterization of crop rhizospheres: an integrated Raman spectroscopy and microbiome approach in conventional and organic agriculture.Frontiers in microbiology · 2025Article
- Activity of novel virus families infecting soil nitrifiers is concomitant with host niche differentiation.The ISME journal · 2024Article
- Nitrogen and phosphorous acquisition strategies drive coexistence patterns among archaeal lineages in soil.The ISME journal · 2023Article
- Transcriptomic Insights into Archaeal Nitrification in the Amundsen Sea Polynya, Antarctica.Journal of microbiology (Seoul, Korea) · 2023Article
- Nitrification and beyond: metabolic versatility of ammonia oxidising archaea.The ISME journal · 2023Review
- Soybean and Cotton Spermosphere Soil Microbiome Shows Dominance of Soilborne Copiotrophs.Microbiology spectrum · 2023Article
- Unexpected complexity of the ammonia monooxygenase in archaea.The ISME journal · 2023Article
- Propagation of viral genomes by replicating ammonia-oxidising archaea during soil nitrification.The ISME journal · 2023Article
- Effect of chlorantraniliprole on soil bacterial and fungal diversity and community structure.Heliyon · 2023Article
- Ecological Aerobic Ammonia and Methane Oxidation Involved Key Metal Compounds, Fe and Cu.Life (Basel, Switzerland) · 2022Review
- Copper mobilisation from Cu sulphide minerals by methanobactin: Effect of pH, oxygen and natural organic matter.Geobiology · 2022Article
- Response mechanism of Vibrio parahaemolyticus at high pressure revealed by transcriptomic analysis.Applied microbiology and biotechnology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ammonia-oxidizing archaea (AOA) are widespread in nature and are involved in nitrification, an essential process in the global nitrogen cycle. The enzymes for ammonia oxidation and electron transport rely heavily on copper (Cu), which can be limited in nature. In this study the model soil archaeon Nitrososphaera viennensis was investigated via transcriptomic analysis to gain insight regarding possible Cu uptake mechanisms and compensation strategies when Cu becomes limiting. Upon Cu limitation, N. viennensis exhibited impaired nitrite production and thus growth, which was paralleled by downregulation of ammonia oxidation, electron transport, carbon fixation, nucleotide, and lipid biosynthesis pathway genes. Under Cu-limitation, 1547 out of 3180 detected genes were differentially expressed, with 784 genes upregulated and 763 downregulated. The most highly upregulated genes encoded proteins with a possible role in Cu binding and uptake, such as the Cu chelator and transporter CopC/D, disulfide bond oxidoreductase D (dsbD), and multicopper oxidases. While this response differs from the marine strain Nitrosopumilus maritimus, conserved sequence motifs in some of the Cu-responsive genes suggest conserved transcriptional regulation in terrestrial AOA. This study provides possible gene regulation and energy conservation mechanisms linked to Cu bioavailability and presents the first model for Cu uptake by a soil AOA.
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